ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2010
An EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Integrated airway epithelial signaling networks linking allergen-driven inflammation to airway remodeling in asthma.Frontiers in immunology · 2026Review
- Mechanical induction in metazoan development and evolution: from earliest multi-cellular organisms to modern animal embryos.Nature communications · 2024Review
- Genomic signatures of the unjamming transition in compressed human bronchial epithelial cells.Science advances · 2021Article
- Airway mechanical compression: its role in asthma pathogenesis and progression.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Oleanolic acid induces migration in Mv1Lu and MDA-MB-231 epithelial cells involving EGF receptor and MAP kinases activation.PloS one · 2017Article
- Cell Jamming in the Airway Epithelium.Annals of the American Thoracic Society · 2016Review
- YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression.Oncogene · 2015Article
- Coming to terms with tissue engineering and regenerative medicine in the lung.American journal of physiology. Lung cellular and molecular physiology · 2015Review
- Putting the Squeeze on Airway Epithelia.Physiology (Bethesda, Md.) · 2015Review
- Hypercapnia attenuates ventilator-induced lung injury via a disintegrin and metalloprotease-17.The Journal of physiology · 2014Article
- miR-146a regulates mechanotransduction and pressure-induced inflammation in small airway epithelium.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Ion Electrodiffusion Governs Silk Electrogelation.Soft matter · 2012Article
- Mechanobiology in lung epithelial cells: measurements, perturbations, and responses.Comprehensive Physiology · 2012Review
- TNF-α-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells.American journal of respiratory cell and molecular biology · 2011Article
- A 3-D model of ligand transport in a deforming extracellular space.Biophysical journal · 2010Article
- The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The mechanical landscape in biological systems can be complex and dynamic, with contrasting sustained and fluctuating loads regularly superposed within the same tissue. How resident cells discriminate between these scenarios to respond accordingly remains largely unknown. Here, we show that a step increase in compressive stress of physiological magnitude shrinks the lateral intercellular space between bronchial epithelial cells, but does so with strikingly slow exponential kinetics (time constant approximately 110 s). We confirm that epidermal growth factor (EGF)-family ligands are constitutively shed into the intercellular space and demonstrate that a step increase in compressive stress enhances EGF receptor (EGFR) phosphorylation with magnitude and onset kinetics closely matching those predicted by constant-rate ligand shedding in a slowly shrinking intercellular geometry. Despite the modest degree and slow nature of EGFR activation evoked by compressive stress, we find that the majority of transcriptomic responses to sustained mechanical loading require ongoing activity of this autocrine loop, indicating a dominant role for mechanotransduction through autocrine EGFR signaling in this context. A slow deformation response to a step increase in loading, accompanied by synchronous increases in ligand concentration and EGFR activation, provides one means for cells to mount a selective and context-appropriate response to a sustained change in mechanical environment.
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Registered trials
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