ArticleEnvironmental health perspectives2010
Associations of serum concentrations of organochlorine pesticides with breast cancer and prostate cancer in U.S. adults.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02530814 (Organochlorine Pesticide Exposure in Residents Near Lake Apopka), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Organochlorine Pesticide Exposure in Residents Near Lake Apopka
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 164 citations in OpenAlex.
- Body concentrations of persistent organic pollutants and prostate cancer: a meta-analysis.Environmental science and pollution research international · 2015Pooled it
- Farming, reported pesticide use, and prostate cancer.American journal of men's health · 2013Pooled it
- Obesogens in Prostate Cancer: An Endocrine and Metabolic Threat.Current obesity reports · 2026Review
- Endocrine-disrupting chemicals as prostate carcinogens.Nature reviews. Urology · 2025Review
- Biodetector for chlordane using doped InPRSC advances · 2024Article
- Unlocking the mystery associated with infertility and prostate cancer: an update.Medical oncology (Northwood, London, England) · 2023Review
- Xeno-Estrogenic Pesticides and the Risk of Related Human Cancers.Journal of xenobiotics · 2022Review
- Environmental Phenol and Paraben Exposure Risks and Their Potential Influence on the Gene Expression Involved in the Prognosis of Prostate Cancer.International journal of molecular sciences · 2022Article
- Temporal Trends of Exposure to Organochlorine Pesticides in the United States: A Population Study from 2005 to 2016.International journal of environmental research and public health · 2022Article
- Article
- Prenatal, perinatal, and postnatal factors associated with autism spectrum disorder cases in Xuzhou, China.Translational pediatrics · 2021Article
- Glutathione S-transferase activity and genetic polymorphisms associated with exposure to organochloride pesticides in Todos Santos, BCS, Mexico: a preliminary study.Environmental science and pollution research international · 2020Article
- Herbicide, fumigant, and fungicide use and breast cancer risk among farmers' wives.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- Serum concentrations of DDE, PCBs, and other persistent organic pollutants and mammographic breast density in Triana, Alabama, a highly exposed population.Environmental research · 2020Article
- Genetic susceptibility of CYP1A1 gene and risk of pesticide exposure in prostate cancer.Cancer biomarkers : section A of Disease markers · 2020Article
- Chromosomal Instability in Farmers Exposed to Pesticides: High Prevalence of Clonal and Non-Clonal Chromosomal Alterations.Risk management and healthcare policy · 2020Article
- Self-reported residential pesticide use and survival after breast cancer.International journal of hygiene and environmental health · 2019Article
- Association of brain heptachlor epoxide and other organochlorine compounds with lewy pathology.Movement disorders : official journal of the Movement Disorder Society · 2019Article
- Low prevalence of anti-xenobiotic antibodies among the occupationally exposed individuals is associated with a high risk of cancer.Cancer medicine · 2019Article
- Expression of the miR-190 family is increased under DDT exposure in vivo and in vitro.Molecular biology reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOrganochlorine (OC) pesticides are a group of environmental endocrine disruptors that may be associated with an increased risk for hormone-related cancers including cancers of the breast and prostate. However, epidemiologic evidence is limited and inconsistent. OBJECTIVES AND
methodsWe used 1999-2004 National Health and Nutrition Examination Survey data to examine associations between serum concentrations of OC pesticides and prostate and breast cancers.
resultsAfter adjustment for other covariates, serum concentrations of beta-hexachlorocyclohexane (HCH) (p for trend = 0.02), trans-nonachlor (p for trend = 0.002), and dieldrin (p for trend = 0.04) were significantly associated with the risk of prevalent prostate cancer. Adjusted odds ratios for the second and third tertiles of detectable values were 1.46 [95% confidence interval (CI), 0.52-4.13] and 3.36 (95% CI, 1.24-9.10) for beta-HCH; 5.84 (95% CI, 1.06-32.2) and 14.1 (95% CI, 2.55-77.9) for trans-nonachlor; and 1.06 (95% CI, 0.30-3.73) and 2.74 (95% CI, 1.01-7.49) for dieldrin compared with concentrations in the lowest tertile or below the limit of detection. However, there was no positive association between serum concentrations of OC pesticides and breast cancer prevalence.
conclusionAlthough further study is necessary to confirm these findings, these results suggest that OC pesticide exposures may have a significant effect on cancer risk. Efforts to reduce worldwide OC use are warranted.
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Registered trials
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