SynthesisEnvironmental health perspectives2010
Residential pesticides and childhood leukemia: a systematic review and meta-analysis.
Synthesis in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Use of Systematic Review and Meta-Analysis in Environmental Health Epidemiology: a Systematic Review and Comparison with Guidelines.Current environmental health reports · 2015Pooled it
- Exposure to organochlorine pollutants and type 2 diabetes: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Establishing environmental causes of childhood cancer: a view from the IARC Monographs.UCL open. Environment · 2026Article
- The Determining of Pesticide Residue Levels in Children Diagnosed with Acute Leukemia in Cukurova Region, Turkiye.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Early Infection Incidence and Risk of Acute Leukemia Development Among Mexican Children.Cancers · 2025Article
- The Level of Adherence to Organic Food Consumption and Risk of Cancer: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- Cumulative Exposure to Unconventional Natural Gas Development and the Risk of Childhood Cancer: A Registry-Based Case-Control Study.International journal of environmental research and public health · 2025Article
- Exposure to persistent organic pollutants in newborn dried blood spots and childhood acute myeloid leukemia.Environmental research · 2024Article
- Glyphosate in house dust and risk of childhood acute lymphoblastic leukemia in California.Environment international · 2023Article
- Incidence and Risk Factors of Acute Leukemias in Armenia: A Population-Based Study.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- The insecticides permethrin and chlorpyrifos show limited genotoxicity and no leukemogenic potential in human and murine hematopoietic stem progenitor cells.Haematologica · 2022Article
- Environmental Risk Factors for Childhood Acute Lymphoblastic Leukemia: An Umbrella Review.Cancers · 2022Review
- [Skeletal manifestations of systemic hematologic disorders].Der Radiologe · 2021Review
- Residential exposure to carbamate, organophosphate, and pyrethroid insecticides in house dust and risk of childhood acute lymphoblastic leukemia.Environmental research · 2021Article
- Why We Will Continue to Lose Our Battle with Cancers If We Do Not Stop Their Triggers from Environmental Pollution.International journal of environmental research and public health · 2021Review
- A Critical Review of the Status of Pesticide Exposure Management in Malawi.International journal of environmental research and public health · 2020Review
- Rio Birth Cohort Study on Environmental Exposure and Childhood Development - PIPA Project.Annals of global health · 2020Article
- Prenatal pesticide exposure and childhood leukemia - A California statewide case-control study.International journal of hygiene and environmental health · 2020Article
- A Pilot Study Evaluating Organochlorine and Organophosphate Pesticide Exposure in Children and Adolescents of Mexican Descent Residing in Hidalgo County, Texas.Journal of immigrant and minority health · 2019Article
- Is There Etiologic Heterogeneity between Subtypes of Childhood Acute Lymphoblastic Leukemia? A Review of Variation in Risk by Subtype.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe conducted a systematic review and meta-analysis of previous observational epidemiologic studies examining the relationship between residential pesticide exposures during critical exposure time windows (preconception, pregnancy, and childhood) and childhood leukemia. DATA SOURCES: Searches of MEDLINE and other electronic databases were performed (1950-2009). Reports were included if they were original epidemiologic studies of childhood leukemia, followed a case-control or cohort design, and assessed at least one index of residential/household pesticide exposure/use. No language criteria were applied. DATA EXTRACTION: Study selection, data abstraction, and quality assessment were performed by two independent reviewers. Random effects models were used to obtain summary odds ratios (ORs) and 95% confidence intervals (CIs). DATA SYNTHESIS: Of the 17 identified studies, 15 were included in the meta-analysis. Exposures during pregnancy to unspecified residential pesticides (summary OR = 1.54; 95% CI, 1.13-2.11; I2 = 66%), insecticides (OR = 2.05; 95% CI, 1.80-2.32; I2 = 0%), and herbicides (OR = 1.61; 95% CI, 1.20-2.16; I2 = 0%) were positively associated with childhood leukemia. Exposures during childhood to unspecified residential pesticides (OR = 1.38; 95% CI, 1.12-1.70; I2 = 4%) and insecticides (OR = 1.61; 95% CI, 1.33-1.95; I2 = 0%) were also positively associated with childhood leukemia, but there was no association with herbicides.
conclusionsPositive associations were observed between childhood leukemia and residential pesticide exposures. Further work is needed to confirm previous findings based on self-report, to examine potential exposure-response relationships, and to assess specific pesticides and toxicologically related subgroups of pesticides in more detail.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.