Evidence map›Paper›PMID 20056575›Full record

ArticleEnvironmental health perspectives2010

Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook.

Graham Van Aggelen, Gerald T Ankley, William S Baldwin, Daniel W Bearden, William H Benson, J Kevin Chipman, Tim W Collette, John A Craft, Nancy D Denslow, Michael R Embry and 23 more

Abstract readConference Proceedings
In one paragraph

Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Metabolome response to anthropogenic contamination on microalgae: a review.Metabolomics : Official journal of the Metabolomic Society · 2019
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment.Toxicological sciences : an official journal of the Society of Toxicology · 2017
    Review
  20. Natural variability of enzymatic biomarkers in freshwater invertebrates.Environmental science and pollution research international · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Graham Van AggelenEnvironment Canada, Pacific Environmental Science Centre, British Columbia, Canada.
Gerald T Ankley
William S Baldwin
Daniel W Bearden
William H Benson
J Kevin Chipman
Tim W Collette
John A Craft
Nancy D Denslow
Michael R Embry
Francesco Falciani
Stephen G George
Caren C Helbing
Paul F Hoekstra
Taisen Iguchi
Yoshi Kagami
Ioanna Katsiadaki
Peter Kille
Li Liu
Peter G Lord
Terry McIntyre
Anne O'Neill
Heather Osachoff
Ed J Perkins
Eduarda M Santos
Rachel C Skirrow
Jason R Snape
Charles R Tyler
Don Versteeg
Mark R Viant
David C Volz
Tim D Williams
Lorraine Yu

Funding

The Role of Cyp2b in Toxicant Metabolism and SensitivityR15ES017321 · NIEHS · CLEMSON UNIVERSITY · PI BALDWIN, WILLIAM S · 2009 to 2020
$1.3M
National Centre for the Replacement, Refinement and Reduction of Animals in Research G0800733/1NIEHS NIH HHS R15 ES017321
6 · The paper itself

Abstract

backgroundIn this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by the U.K. Natural Environment Research Council (Fish Toxicogenomics-Moving into Regulation and Monitoring, held 21-23 April 2008 at the Pacific Environmental Science Centre, Vancouver, BC, Canada).

objectivesThe consortium from government agencies, academia, and industry addressed three topics: progress in ecotoxicogenomics, regulatory perspectives on roadblocks for practical implementation of toxicogenomics into risk assessment, and dealing with variability in data sets. DISCUSSION: Participants noted that examples of successful application of omic technologies have been identified, but critical studies are needed to relate molecular changes to ecological adverse outcome. Participants made recommendations for the management of technical and biological variation. They also stressed the need for enhanced interdisciplinary training and communication as well as considerable investment into the generation and curation of appropriate reference omic data.

conclusionsThe participants concluded that, although there are hurdles to pass on the road to regulatory acceptance, omics technologies are already useful for elucidating modes of action of toxicants and can contribute to the risk assessment process as part of a weight-of-evidence approach.

Indexed as

EcotoxicologyEnvironmental MonitoringAnimalsFishesInternational AgenciesRisk AssessmentToxicogenetics

Identifiers

PMID20056575
PMCPMC2831950

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.