ArticleEnvironmental health perspectives2010
Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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24 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Parental Tobacco Smoking and Acute Myeloid Leukemia: The Childhood Leukemia International Consortium.American journal of epidemiology · 2016Pooled it
- Pharmacogenomic characterization of gemcitabine response--a framework for data integration to enable personalized medicine.Pharmacogenetics and genomics · 2014Trial
- Environmental Pesticide Exposure in the Etiology of Pediatric Brain Tumors and Leukemia: A Scoping Review of Epidemiological Studies.International journal of cancer · 2026Article
- Article
- Parental Pesticide Exposure and Childhood Brain Cancer: A Systematic Review and Meta-Analysis Confirming the IARC/WHO Monographs on Some Organophosphate Insecticides and Herbicides.Children (Basel, Switzerland) · 2021Review
- Residential proximity to pesticide application as a risk factor for childhood central nervous system tumors.Environmental research · 2021Article
- Different working conditions shift the genetic damage levels of pesticide-exposed agriculture workers.Environmental science and pollution research international · 2020Article
- Advancing neuro-oncology of glial tumors from big data and multidisciplinary studies.Journal of neuro-oncology · 2020Review
- Germline genetic landscape of pediatric central nervous system tumors.Neuro-oncology · 2019Review
- Farmers' Perception of the Health Effects of Agrochemicals in Southeast Nigeria.Journal of health & pollution · 2018Article
- Public awareness of central nervous system tumors in the Kingdom of Saudi Arabia.Neurosciences (Riyadh, Saudi Arabia) · 2018Article
- Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility.Oncotarget · 2016Article
- Research Review: Environmental exposures, neurodevelopment, and child mental health - new paradigms for the study of brain and behavioral effects.Journal of child psychology and psychiatry, and allied disciplines · 2016Review
- In Utero and Early-Life Exposure to Ambient Air Toxics and Childhood Brain Tumors: A Population-Based Case-Control Study in California, USA.Environmental health perspectives · 2016Article
- Childhood brain tumor epidemiology: a brain tumor epidemiology consortium review.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Review
- PON1 Q192R polymorphism (rs662) is associated with childhood embryonal tumors.Molecular biology reports · 2014Article
- Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients.The pharmacogenomics journal · 2013Article
- Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children.Croatian medical journal · 2013Article
- The potential effect of gender in CYP1A1 and GSTM1 genotype-specific associations with pediatric brain tumor.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Incidence of adult brain cancers is higher in countries where the protozoan parasite Toxoplasma gondii is common.Biology letters · 2012Article
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6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundInsecticides that target the nervous system may play a role in the development of childhood brain tumors (CBTs). Constitutive genetic variation affects metabolism of these chemicals.
methodsWe analyzed population-based case-control data to examine whether CBT is associated with the functional genetic polymorphisms PON1C-108T, PON1Q192R, PON1L55M, BCHEA539T, FMO1C-9536A, FMO3E158K, ALDH3A1S134A, and GSTT1 (null). DNA was obtained from newborn screening archives for 201 cases and 285 controls, <or= 10 years of age, and born in California or Washington State between 1978 and 1990. Conception-to-diagnosis home insecticide treatment history was ascertained by interview.
resultsWe observed no biologically plausible main effects for any of the metabolic polymorphisms with CBT risk. However, we observed strong interactions between genotype and insecticide exposure during childhood. Among exposed children, CBT risk increased per PON1-108T allele [odds ratio (OR) = 1.8; 95% confidence interval (CI), 1.1-3.0] and FMO1-9536A (*6) allele (OR = 2.7; 95% CI, 1.2-5.9), whereas among children never exposed, CBT risk was not increased (PON1: OR = 0.7; 95% CI, 0.5-1.0, interaction p = 0.005; FMO1: OR = 1.0; 95% CI, 0.6-1.6, interaction p = 0.009). We observed a similar but statistically nonsignificant interaction between childhood exposure and BCHEA539T (interaction p = 0.08). These interactions were present among both Hispanic and non-Hispanic white children.
conclusionBased on known effects of these variants, these results suggest that exposure in childhood to organophosphorus and perhaps to carbamate insecticides in combination with a reduced ability to detoxify them may be associated with CBT. Confirmation in other studies is required.
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