Evidence map›Paper›PMID 20056562›Full record

ArticleEnvironmental health perspectives2010

Urinary concentrations of four parabens in the U.S. population: NHANES 2005-2006.

Antonia M Calafat, Xiaoyun Ye, Lee-Yang Wong, Amber M Bishop, Larry L Needham

2 registry-linked trialsOpen access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 180 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 5 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05780047 nacompletednot on this mapstarted 2022, after this paper: background citation

Personalized Mobile Intervention to Reduce Exposure to Endocrine Disrupting Chemicals (EDCs) in Women of Child-Bearing Age and Their Partners

TypeinterventionalSponsorMillion Marker Wellness, Inc.Ran2022 to 2022Enrolled434ConditionsEndocrine Disrupting Chemicals, Environmental Exposure, Health Literacy, Bisphenol AArmsMail-in Urine Test for EDCs
NCT07461857 nacompletednot on this mapstarted 2025, after this paper: background citation

Minority-focused Environmental Health Education and Tracking (MEET) Pilot Study

TypeinterventionalSponsorMillion Marker Wellness, Inc.Ran2025 to 2026Enrolled151ConditionsEnvironmental ExposureArmsEducation curriculum
3 · Its place in the literature

Who cites it

180 citing papers in PubMed, 5 syntheses or guidelines pooled it, 449 citations in OpenAlex.

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  17. Young infants' exposure to parabens: lotion use as a potential source of exposure.Journal of exposure science & environmental epidemiology · 2025
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120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Antonia M CalafatDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 , USA. Acalafat@cdc.gov
Xiaoyun Ye
Lee-Yang Wong
Amber M Bishop
Larry L Needham
Centers for Disease Control and Prevention · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParabens are widely used as antimicrobial preservatives in cosmetics, -pharmaceuticals, and food and beverage processing.

objectivesWe assessed exposure to methyl, ethyl, propyl, and butyl parabens in a representative sample of persons >or= 6 years of age in the U.S. general population from the 2005-2006 National Health and Nutrition Examination Survey.

methodsWe analyzed 2,548 urine samples by using online solid-phase extraction coupled to isotope dilution-high-performance liquid chromatography/tandem mass spectrometry.

resultsWe detected methyl paraben (MP) and propyl paraben (PP) in 99.1% and 92.7% of the samples, respectively. We detected ethyl (42.4%) and butyl (47%) parabens less frequently and at median concentrations at least one order of magnitude lower than MP (63.5 microg/L) and PP (8.7 microg/L). Least-square geometric mean (LSGM) concentrations of MP were significantly higher (p <or= 0.01) among non-Hispanic blacks than among non-Hispanic whites except at older ages (>or= 60 years). Adolescent and adult females had significantly higher (p < 0.01) LSGM concentrations of MP and PP than did adolescent and adult males. Females were more likely than males [adjusted odds ratios (ORs) and 95% confidence intervals (CIs): MP, 3.2 (2.99-5.27); PP, 4.19 (2.34-7.49)] and non-Hispanic blacks were more likely than non-Hispanic whites [MP, 4.99 (2.62-9.50); PP, 3.6 (1.86-7.05)] to have concentrations above the 95th percentile.

conclusionsThe general U.S. population was exposed to several parabens during 2005-2006. Differences in the urinary concentrations of MP and PP by sex and race/ethnicity likely reflect the use of personal care products containing these compounds.

Indexed as

AdolescentAdultAgedChildChromatography, High Pressure LiquidEnvironmental ExposureEnvironmental HealthEnvironmental MonitoringFemaleFood PreservativesHumansMaleMiddle AgedParabensPreservatives, PharmaceuticalSolid Phase Extractionbutylparabenethyl-p-hydroxybenzoateFood PreservativesmethylparabenParabensPreservatives, Pharmaceuticalpropylparaben

Identifiers

PMID20056562
PMCPMC2866685
OpenAlexW2032789267

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.