ArticleJournal of cardiothoracic and vascular anesthesia2010
Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery.
Article in Journal of cardiothoracic and vascular anesthesia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Polymorphisms on PAI-1 and ACE genes in association with fibrinolytic bleeding after on-pump cardiac surgery.BMC anesthesiology · 2015Article
- Does incorporation of thromboelastography improve bleeding prediction following adult cardiac surgery?Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 2014Article
- Impact of genetic variation on perioperative bleeding.American journal of hematology · 2008Review
- Genomics: risk and outcomes in cardiac surgery.Anesthesiology clinics · 2008Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveHemorrhage continues to be a major problem after cardiac surgery despite the routine use of antifibrinolytic drugs, with striking inter-patient variability poorly explained by already known risk factors. The authors tested the hypothesis that genetic polymorphisms of inflammatory mediators and cellular adhesion molecules are associated with bleeding after cardiac surgery.
designProspective, observational study.
settingSingle, tertiary referral university heart center.
participantsAdult patients undergoing aortocoronary surgery with cardiopulmonary bypass.
interventionsPatients (n = 759) had 10 mL of blood drawn preoperatively and genomic DNA isolated then genotyped for 17 polymorphisms in 7 candidate genes: tumor necrosis factor, interleukins 1beta and 6, interleukin 1 receptor antagonist, intercellular adhesion molecule-1 (ICAM-1), P-selectin and endothelial leucocyte adhesion molecule-1 (E-selectin). Multivariate analyses were used to relate clinical and genetic factors to bleeding and transfusion. MEASUREMENTS AND MAIN
resultsThe 98G/T polymorphism of the E-selectin gene was independently associated with bleeding after cardiac surgery (p = 0.002), after adjusting for significant clinical predictors (patient size and baseline hemoglobin concentration). There was a gene dose effect according to the number of minor alleles in the genotype; carriers of the minor allele bled 17% (GT) and 54% (TT) more than wild type (GG) genotypes, respectively (p = 0.01). Carriers of the minor allele also had longer activated partial thromboplastin times (p = 0.0023) and increased fresh frozen plasma transfusion (p = 0.03) compared with wild type.
conclusionsThe authors found a dose-related association between the 98T E-selectin polymorphism and bleeding after cardiac surgery, independent of and additive to standard clinical risk factors.
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