ReviewSeminars in immunology2010
Evolution of adaptive immune recognition in jawless vertebrates.
Review in Seminars in immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Programmed DNA Elimination in Vertebrates.Annual review of animal biosciences · 2021Review
- The White-Spotted Bamboo Shark Genome Reveals Chromosome Rearrangements and Fast-Evolving Immune Genes of Cartilaginous Fish.iScience · 2020Article
- Evolutionary perspective on the hematopoietic system through a colonial chordate: allogeneic immunity and hematopoiesis.Current opinion in immunology · 2020Review
- Review
- An Evolutionary Perspective on Yeast Mating-Type Switching.Genetics · 2017Review
- Identification and characterisation of the immune response properties of Lampetra japonica BLNK.Scientific reports · 2016Article
- Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution.Nature genetics · 2013Article
- Appraisal of microbial evolution to commensalism and pathogenicity in humans.Clinical medicine insights. Gastroenterology · 2013Review
- Evolutionary genomics of immunoglobulin-encoding Loci in vertebrates.Current genomics · 2012Article
- CD98 at the crossroads of adaptive immunity and cancer.Journal of cell science · 2012Review
- Shark class II invariant chain reveals ancient conserved relationships with cathepsins and MHC class II.Developmental and comparative immunology · 2012Article
- Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The invention of lymphocytes.Current opinion in immunology · 2011Review
- The origins of vertebrate adaptive immunity.Nature reviews. Immunology · 2010Review
- Genome biology of the cyclostomes and insights into the evolutionary biology of vertebrate genomes.Integrative and comparative biology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
All extant vertebrates possess an adaptive immune system wherein diverse immune receptors are created and deployed in specialized blood cell lineages. Recent advances in DNA sequencing and developmental resources for basal vertebrates have facilitated numerous comparative analyses that have shed new light on the molecular and cellular bases of immune defense and the mechanisms of immune receptor diversification in the "jawless" vertebrates. With data from these key species in hand, it is becoming possible to infer some general aspects of the early evolution of vertebrate adaptive immunity. All jawed vertebrates assemble their antigen-receptor genes through combinatorial recombination of different "diversity" segments into immunoglobulin or T-cell receptor genes. However, the jawless vertebrates employ an analogous, but independently derived set of immune receptors in order to recognize and bind antigens: the variable lymphocyte receptors (VLRs). The means by which this locus generates receptor diversity and achieves antigen specificity is of considerable interest because these mechanisms represent a completely independent strategy for building a large immune repertoire. Therefore, studies of the VLR system are providing insight into the fundamental principles and evolutionary potential of adaptive immune recognition systems. Here we review and synthesize the wealth of data that have been generated towards understanding the evolution of the adaptive immune system in the jawless vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.