ArticleDifferentiation; research in biological diversity2010
Regeneration of acinar cells following ligation of rat submandibular gland retraces the embryonic-perinatal pathway of cytodifferentiation.
Article in Differentiation; research in biological diversity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Single-Cell Transcriptomic Analysis of Salivary Gland Endothelial Cells.Journal of dental research · 2024Article
- The Role of mTOR and Injury in Developing Salispheres.Biomedicines · 2023Article
- Role of quiescent cells in the homeostatic maintenance of the adult submandibular salivary gland.iScience · 2022Article
- Na+/I- symporter expression, function, and regulation in non-thyroidal tissues and impact on thyroid cancer therapy.Endocrine-related cancer · 2021Article
- Comparing development and regeneration in the submandibular gland highlights distinct mechanisms.Journal of anatomy · 2021Article
- Organoid Models for Salivary Gland Biology and Regenerative Medicine.Stem cells international · 2021Review
- Experimental Animal Model Systems for Understanding Salivary Secretory Disorders.International journal of molecular sciences · 2020Review
- Diverse epithelial cell populations contribute to the regeneration of secretory units in injured salivary glands.Development (Cambridge, England) · 2020Article
- Alpha-Lipoic Acid Ameliorates Radiation-Induced Salivary Gland Injury by Preserving Parasympathetic Innervation in Rats.International journal of molecular sciences · 2020Article
- Regional Differences following Partial Salivary Gland Resection.Journal of dental research · 2020Article
- Neurturin-containing laminin matrices support innervated branching epithelium from adult epithelial salispheres.Biomaterials · 2019Article
- Lacrimal Gland Repair after Short-term Obstruction of Excretory Duct in Rabbits.Scientific reports · 2017Article
- Expression of c-kit and Cytokeratin 5 in the Submandibular Gland after Release of Long-Term Ligation of the Main Excretory Duct in Mice.Acta histochemica et cytochemica · 2017Article
- Primary Salivary Human Stem/Progenitor Cells Undergo Microenvironment-Driven Acinar-Like Differentiation in Hyaluronate Hydrogel Culture.Stem cells translational medicine · 2017Article
- Salivary Glands: Stem Cells, Self-duplication, or Both?Journal of dental research · 2015Review
- Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation.PloS one · 2015Article
- Stem cell therapies for the treatment of radiation-induced normal tissue side effects.Antioxidants & redox signaling · 2014Review
- Rapamycin delays salivary gland atrophy following ductal ligation.Cell death & disease · 2014Article
- Pharmacological activation of the EDA/EDAR signaling pathway restores salivary gland function following radiation-induced damage.PloS one · 2014Article
- Modulation of sodium/iodide symporter expression in the salivary gland.Thyroid : official journal of the American Thyroid Association · 2013Article
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3 authors at 1 institution in 1 country.
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Abstract
Rat submandibular gland can regenerate following ligation-induced atrophy, eventually recovering its normal morphology and function. Previous studies have suggested that the regeneration process implies both self-proliferation of existing acini and formation of new acinar cells. One hypothesis is that new acinar cells may differentiate from the ductal cells in a similar fashion to the process of cytodifferentiation occurring during submandibular glandular development. In this study atrophy was induced, under recovery anaesthesia, by applying a metal clip on the main duct of the submandibular gland without including the chorda lingual nerve. After 2 weeks the duct was deligated for 3, 5 or 7 days or 8 weeks and the glands collected. Tissue was prepared for immunohistochemistry, biochemical analysis and RNA extraction. The histology of the regenerated glands shows several normal-looking acini, which have regained their glycoprotein content (AB/PAS positive), data also confirmed by biochemical analysis (SDS-PAGE/PAS). Regenerating tissue was characterized by the presence of embryonic-like branched structures ending with AB/PAS positive acinar cells. The proteins SMG-B and PSP are normally expressed in acinar cell precursors during development but only by intercalated ductal cells in the adult stage. In the adult regenerating gland mRNA levels of both SMG-B and PSP were found to be up-regulated compared to ligated glands and SMG-B expression localized to acinar cells whilst the ductal cells were negative. This study of rat submandibular gland regeneration suggests new acinar cells have differentiated from ducts and express markers of acinar cell precursors in a similar manner to the cytodifferentiation process occurring during glandular development.
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