ArticleBMC genomics2010
Sex-dimorphic gene expression and ineffective dosage compensation of Z-linked genes in gastrulating chicken embryos.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 69 citations in OpenAlex.
- Screening and identification of genes for cell autonomous sex identity in chicken somatic cells.Poultry science · 2026Article
- Chromosome-level reference genome assembly of the gyrfalcon (Falco rusticolus) and population genomics offer insights into the falcon population in Mongolia.Scientific reports · 2025Article
- Dosage compensation of Z sex chromosome genes in avian fibroblast cells.Genome biology · 2023Article
- The good, the bad, and the ugly: Evolutionary and pathological aspects of gene dosage alterations.PLoS genetics · 2021Review
- Genetic Regulation of Avian Testis Development.Genes · 2021Review
- Expression profiling of sexually dimorphic genes in the Japanese quail, Coturnix japonica.Scientific reports · 2020Article
- RNA sequencing reveals a complete but an unconventional type of dosage compensation in the domestic silkwormRoyal Society open science · 2017Article
- The Odour of Sex: Sex-Related Differences in Volatile Compound Composition among Barn Swallow Eggs Carrying Embryos of Either Sex.PloS one · 2016Article
- Identification of candidate gonadal sex differentiation genes in the chicken embryo using RNA-seq.BMC genomics · 2015Article
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- Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo.Development (Cambridge, England) · 2014Article
- Over-expression of DMRT1 induces the male pathway in embryonic chicken gonads.Developmental biology · 2014Article
- Avian sex, sex chromosomes, and dosage compensation in the age of genomics.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Review
- Complete dosage compensation and sex-biased gene expression in the moth Manduca sexta.Genome biology and evolution · 2014Article
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- Manteia, a predictive data mining system for vertebrate genes and its applications to human genetic diseases.Nucleic acids research · 2014Article
- Large sex differences in chicken behavior and brain gene expression coincide with few differences in promoter DNA-methylation.PloS one · 2014Article
- Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.Journal of the American Society of Nephrology : JASN · 2013Article
- Epigenetics and phenotypic variability: some interesting insights from birds.Genetics, selection, evolution : GSE · 2013Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundConsiderable progress has been made in our understanding of sex determination and dosage compensation mechanisms in model organisms such as C. elegans, Drosophila and M. musculus. Strikingly, the mechanism involved in sex determination and dosage compensation are very different among these three model organisms. Birds present yet another situation where the heterogametic sex is the female. Sex determination is still poorly understood in birds and few key determinants have so far been identified. In contrast to most other species, dosage compensation of bird sex chromosomal genes appears rather ineffective.
resultsBy comparing microarrays from microdissected primitive streak from single chicken embryos, we identified a large number of genes differentially expressed between male and female embryos at a very early stage (Hamburger and Hamilton stage 4), long before any sexual differentiation occurs. Most of these genes are located on the Z chromosome, which indicates that dosage compensation is ineffective in early chicken embryos. Gene ontology analyses, using an enhanced annotation tool for Affymetrix probesets of the chicken genome developed in our laboratory (called Manteia), show that among these male-biased genes found on the Z chromosome, more than 20 genes play a role in sex differentiation.
conclusionsThese results corroborate previous studies demonstrating the rather inefficient dosage compensation for Z chromosome in birds and show that this sexual dimorphism in gene regulation is observed long before the onset of sexual differentiation. These data also suggest a potential role of non-compensated Z-linked genes in somatic sex differentiation in birds.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.