ArticleJournal of combinatorial chemistry2010
Diverse methyl sulfone-containing benzo[b]thiophene library via iodocyclization and palladium-catalyzed coupling.
Article in Journal of combinatorial chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Choline Chloride/Urea - Promoted Iodocyclization of 3-Alkynylthiophene-2-carboxamides: A Green Synthesis of 4-Iodo-7H-thieno[2,3-c]pyran-7-imines and Their Coupling Reactions in Deep Eutectic Solvents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- A reagent to access methyl sulfones.Nature communications · 2025Article
- Halogen-Bonded Supramolecular Parallelograms: From Self-Complementary Iodoalkyne Halogen-Bonded Dimers to 1:1 and 2:2 Iodoalkyne Halogen-Bonded Cocrystals.Crystal growth & design · 2024Article
- Synthesis of 3(2)-phosphonylated thiazolo[3,2-Beilstein journal of organic chemistry · 2020Article
- Palladium(II) Catalyzed Cyclization-Carbonylation-Cyclization Coupling Reaction of (ortho-Alkynyl Phenyl) (Methoxymethyl) Sulfides Using Molecular Oxygen as the Terminal Oxidant.Molecules (Basel, Switzerland) · 2016Article
- N-Aryl Isoleucine Derivatives as Angiotensin II AT2 Receptor Ligands.ChemistryOpen · 2014Article
- Solution-phase synthesis of a highly substituted furan library.ACS combinatorial science · 2012Article
- Parallel synthesis of a desketoraloxifene analogue library via iodocyclization/palladium-catalyzed coupling.ACS combinatorial science · 2011Article
- Highly substituted lactone/ester-containing furan library by the palladium-catalyzed carbonylation of hydroxyl-substituted 3-iodofurans.ACS combinatorial science · 2011Article
- Automated synthesis of a 184-member library of thiadiazepan-1,1-dioxide-4-ones.ACS combinatorial science · 2011Article
- A new approach to desketoraloxifene analogs from oxygen-bearing 3-iodobenzo[b]thiophenes prepared via iodocyclization.Tetrahedron letters · 2010Article
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3 authors.
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Abstract
Parallel solution-phase methods for the synthesis of a 72-membered benzo[b]thiophene library are reported. Medicinally interesting, drug-like, methyl sulfone-substituted benzo[b]thiophenes have been prepared by the palladium-catalyzed substitution of 3-iodobenzo[b]thiophenes by Suzuki-Miyaura, Sonogashira, Heck, carboalkoxylation, and aminocarbonylation chemistry. The key intermediates for library generation, methyl sulfone-containing 3-iodobenzo[b]thiophenes, are readily prepared by iodocyclization and oxidation methodologies from readily available alkynes.
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