ArticlePlant molecular biology2010
Genome-wide profiling of histone H3 lysine 9 acetylation and dimethylation in Arabidopsis reveals correlation between multiple histone marks and gene expression.
Article in Plant molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Who cites it
89 citing papers in PubMed, 173 citations in OpenAlex.
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- Unveiling the mechanism of broad-spectrum blast resistance in rice: The collaborative role of transcription factor OsGRAS30 and histone deacetylase OsHDAC1.Plant biotechnology journal · 2024Article
- Rice responds to Spodoptera frugiperda infestation via epigenetic regulation of H3K9ac in the jasmonic acid signaling and phenylpropanoid biosynthesis pathways.Plant cell reports · 2024Article
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- Organ-specific characteristics govern the relationship between histone code dynamics and transcriptional reprogramming during nitrogen response in tomato.Communications biology · 2023Article
- Drought-Stress-Related Reprogramming of Gene Expression in Barley Involves Differential Histone Modifications at ABA-Related Genes.International journal of molecular sciences · 2023Article
- The Global Changes of N6-methyldeoxyadenosine in Response to Low Temperature inPlants (Basel, Switzerland) · 2023Article
- Development of Chromatin Immunoprecipitation for the Analysis of Histone Modifications in Red Macroalga Neopyropia yezoensis (Rhodophyta).Molecular biotechnology · 2023Article
- Histone modifications and DNA methylation act cooperatively in regulating symbiosis genes in the sea anemone Aiptasia.BMC biology · 2022Article
- Review
- Reprogramming rice leaves: another layer of senescence regulation.Journal of experimental botany · 2022Article
- miR778 mediates gene expression, histone modification, and DNA methylation during cyst nematode parasitism.Plant physiology · 2022Article
- Sustained defense response via volatile signaling and its epigenetic transcriptional regulation.Plant physiology · 2022Article
- An Epigenetic Alphabet of Crop Adaptation to Climate Change.Frontiers in genetics · 2022Review
- Genomic Marks Associated with Chromatin Compartments in the CTCF, RNAPII Loop and Genomic Windows.International journal of molecular sciences · 2021Article
- Review
- Polycomb Repressive Complex 2 and KRYPTONITE regulate pathogen-induced programmed cell death in Arabidopsis.Plant physiology · 2021Article
29 more citing papers are in PubMed but not listed here.
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6 authors at 3 institutions in 2 countries.
Funding
Abstract
Lysine residue 9 of histone H3 can either be acetylated or mono-, di-, or tri-methylated. These epigenetic states have a diverse impact on regulating gene transcriptional activity and chromatin organization. H3K9ac is invariably correlated with transcriptional activation, whereas H3K9me2 has been reported to be mainly located in constitutive heterochromatin in Arabidopsis. Here, we present epigenetic landscapes for histone H3 lysine 9 acetylation (H3K9ac) and dimethylation (H3K9me2) in Arabidopsis seedlings. The results show that H3K9ac targeted 5,206 non-transposable element (non-TE) genes and 321 transposable elements (TEs), whereas H3K9me2 targeted 2,281 TEs and 1,112 non-TE genes. H3K9ac was biased towards the 5' end of genes and peaked at the ATG position, while H3K9me2 tended to span the entire gene body. H3K9ac correlated with high gene expression, while H3K9me2 correlated with low expression. Analyses of H3K9ac and H3K9me2 with the available datasets of H3K27me3 and DNA methylation revealed a correlation between the occurrence of multiple epigenetic modifications and gene expression. Genes with H3K9ac alone were actively transcribed, while genes that were also modified by either H3K27me3 or DNA methylation showed a lower expression level, suggesting that a combination of repressive marks weakened the positive regulatory effect of H3K9ac. Furthermore, we observed a significant increase of the H3K9ac modification level of selected target genes in hda19 (histone deacetylase 19) mutant seedlings, which indicated that HDA19 plays an important role in regulating the level of H3K9ac and thereby influencing the transcriptional activity in young seedlings.
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