Trial reportClinical oral investigations2011
Comparative study of DFDBA in combination with enamel matrix derivative versus DFDBA alone for treatment of periodontal intrabony defects at 12 months post-surgery.
Trial report in Clinical oral investigations, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Combination of Enamel Matrix Derivatives with Bone Graft vs Bone Graft Alone in the Treatment of Periodontal Intrabony and Furcation Defects: A Systematic Review and Meta-Analysis.Oral health & preventive dentistry · 2024Pooled it
- Efficacy of Adjunctive Bioactive Materials in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis.BioMed research international · 2018Pooled it
- Enamel matrix derivative and bone grafts for periodontal regeneration of intrabony defects. A systematic review and meta-analysis.Clinical oral investigations · 2015Pooled it
- Adjunctive use of enamel matrix derivatives to porcine-derived xenograft for the treatment of one-wall intrabony defects: Two-year longitudinal results of a randomized controlled clinical trial.Journal of periodontology · 2020Trial
- Four-year results following treatment of intrabony periodontal defects with an enamel matrix derivative alone or combined with a biphasic calcium phosphate.Clinical oral investigations · 2012Trial
- Evaluation of an angio-osseo inductive bone ceramic versus demineralised freeze-dried bone allograft in the treatment of periodontal intrabony defects: a randomised controlled clinical trial.Biomaterial investigations in dentistry · 2026Article
- The impact of selcopintide on periodontal regeneration in a class II furcation defect model: a radiographic and histomorphometric analysis.Clinical oral investigations · 2025Article
- Article
- Clinical and radiographic evaluation of demineralized freeze-dried bone allograft with concentrated growth factor versus concentrated growth factor alone in the treatment of intrabony defects.Medicine and pharmacy reports · 2021Article
- IFN-γR2 is strongly expressed on endothelial cells of gingival tissues from patients with chronic periodontitis.Journal of applied oral science : revista FOB · 2018Article
- The impact of fatwas on patients' acceptance of enamel matrix derivatives for periodontal regeneration in Saudi Arabia.Patient preference and adherence · 2018Article
- Bone grafting material in combination with Osteogain for bone repair: a rat histomorphometric study.Clinical oral investigations · 2016Article
- In vitro characterization of a synthetic calcium phosphate bone graft on periodontal ligament cell and osteoblast behavior and its combination with an enamel matrix derivative.Clinical oral investigations · 2014Article
- Effects of enamel matrix proteins in combination with a bovine-derived natural bone mineral for the repair of bone defects.Clinical oral investigations · 2014Article
- Comparison of bone regeneration using three demineralized freeze-dried bone allografts: A histological and histomorphometric study in rabbit calvaria.Dental research journal · 2012Article
- Human periodontal ligament fibroblasts stimulated by nanocrystalline hydroxyapatite paste or enamel matrix derivative. An in vitro assessment of PDL attachment, migration, and proliferation.Clinical oral investigations · 2012Article
- Clinical and radiographic evaluation of platelet-rich fibrin as an adjunct to bone grafting demineralized freeze-dried bone allograft in intrabony defects.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this randomized double-blind, clinical trial was to compare the use of enamel matrix derivative (EMD) and demineralised freeze-dried bone allografts (DFDBA) with DFDBA alone for the treatment of human periodontal intrabony defects at 12 months post-surgery. Fifty-six intrabony osseous defects in 56 periodontis patients were randomly assigned to the test group (DFDBA + EMD) or the control group (DFDBA) for periodontal treatment. Clinical and radiographic measurements were made at the baseline and after 12 months. Compared to baseline, the 12-month results indicated that both treatment modalities resulted in significant changes in all clinical parameters (gingival index, bleeding on probing, probing depth (PD), clinical attachment level (CAL), gingival recession; P < 0.05) and radiographic parameters (hard tissue fill (HTF) and bone depth reduction; P <0.05). Furthermore, statistically significant differences were found in the test group compared to the control group in PD reduction (5.0 mm vs. 4.0 mm; P < 0.05), CAL gain (4.0 mm vs. 3.25 mm), and HTF (4.0 mm vs. 3.5 mm; P < 0.05). In the test group, 25% of sites gained > 4 mm of CAL, while in the control group, 7.1% of sites gained > 4 mm of CAL. Both treatments showed a good soft and hard periodontal tissue response. At 12 months post-surgery, the combined use of DFDBA and EMD seemed to produce a statistically significant improvement of PD reduction, CAL gain, and HTF.
Indexed as
Identifiers
20054593What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.