ArticleInternational journal of nanomedicine2009
Antibacterial efficacy of core-shell nanostructures encapsulating gentamicin against an in vivo intracellular Salmonella model.
Article in International journal of nanomedicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Effect of Gentamicin Sulfate and Polymeric Polyethylene Glycol Coating on the Degradation and Cytotoxicity of Iron-Based Biomaterials.ACS omega · 2024Article
- Immunomodulation and targeted drug delivery with high intensity focused ultrasound (HIFU): Principles and mechanisms.Pharmacology & therapeutics · 2023Review
- Antibacterial Efficacies of Nanostructured Aminoglycosides.ACS omega · 2022Review
- Liposomes as a Nanoplatform to Improve the Delivery of Antibiotics intoPharmaceutics · 2021Article
- Lipid-based nanosystems for targeting bone implant-associated infections: current approaches and future endeavors.Drug delivery and translational research · 2021Review
- Nanomedicines for the Efficient Treatment of Intracellular Bacteria: The "ART" Principle.Frontiers in chemistry · 2021Review
- Treatment of Brucellosis in Guinea Pigs via a Combination of Engineered Novel pH-Responsive Curcumin Niosome Hydrogel and Doxycycline-Loaded Chitosan-Sodium Alginate Nanoparticles: an In Vitro and In Vivo Study.AAPS PharmSciTech · 2020Article
- Novel Polymeric Nanocarriers Reduced Zinc and Doxycycline Toxicity in the NematodeAntioxidants (Basel, Switzerland) · 2019Article
- A review on nanosystems as an effective approach against infections ofInternational journal of nanomedicine · 2018Review
- Targeting the hard to reach: challenges and novel strategies in the treatment of intracellular bacterial infections.British journal of pharmacology · 2017Review
- Effect of strontium substitution on the cytocompatibility and 3-D scaffold structure for the xSrO-(10-x) MgO-60SiOJournal of materials science. Materials in medicine · 2017Article
- Antimicrobial Polymers in the Nano-World.Nanomaterials (Basel, Switzerland) · 2017Review
- Synthesis, cytotoxicity, and hydroxyapatite formation in 27-Tris-SBF for sol-gel based CaO-P2O5-SiO2-B2O3-ZnO bioactive glasses.Scientific reports · 2014Article
- Aminoglycoside antibiotics: structure, functions and effects on in vitro plant culture and genetic transformation protocols.Plant cell reports · 2010Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pluronic based core-shell nanostructures encapsulating gentamicin were designed in this study. Block copolymers of (PAA(+/-)Na-b-(PEO-b-PPO-b-PEO)-b-PAA(+/-)Na) were blended with PAA(-) Na(+) and complexed with the polycationic antibiotic gentamicin to form nanostructures. Synthesized nanostructures had a hydrodynamic diameter of 210 nm, zeta potentials of -0.7 (+/-0.2), and incorporated approximately 20% by weight of gentamicin. Nanostructures upon co-incubation with J774A.1 macrophage cells showed no adverse toxicity in vitro. Nanostructures administered in vivo either at multiple dosage of 5 microg g(-1) or single dosage of 15 microg g(-1) in AJ-646 mice infected with Salmonella resulted in significant reduction of viable bacteria in the liver and spleen. Histopathological evaluation for concentration-dependent toxicity at a dosage of 15 microg g(-1) revealed mineralized deposits in 50% kidney tissues of free gentamicin-treated mice which in contrast was absent in nanostructure-treated mice. Thus, encapsulation of gentamicin in nanostructures may reduce toxicity and improve in vivo bacterial clearance.
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Registered trials
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