ArticleJournal of perinatology : official journal of the California Perinatal Association2010
Reference ranges for blood concentrations of eosinophils and monocytes during the neonatal period defined from over 63 000 records in a multihospital health-care system.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Use of a computerized C-reactive protein (CRP) based sepsis evaluation in very low birth weight (VLBW) infants: a five-year experience.PloS one · 2013Trial
- Age-adjusted eosinophilia in preterm infants with feeding intolerance: a retrospective cohort study.BMC gastroenterology · 2026Article
- ICSH Recommendations for Monocyte Cell Lineage Morphologic Identification, Nomenclature Harmonization, and Utilization as a Biomarker.International journal of laboratory hematology · 2026Review
- Establishing Reference Ranges and Evaluating Clinical Factors of the Complete Blood Count in Neonates Admitted to a Neonatal Intensive Care Unit.International journal of laboratory hematology · 2026Article
- Neonatal leucocyte cell population data: reference intervals and relevance for detecting sepsis and necrotizing enterocolitis.Pediatric research · 2026Article
- Association Between a Decrease in Blood Monocyte Counts and Necrotizing Enterocolitis in Preterm Infants.Cureus · 2025Article
- Gestational age-specific hematological features in preterm infants with necrotizing enterocolitis.Pediatric research · 2024Article
- Neonatal hematological parameters: the translational aspect of developmental hematopoiesis.Annals of hematology · 2023Review
- Nomogram for predicting fulminant necrotizing enterocolitis.Pediatric surgery international · 2023Article
- Immunopathogenesis of patients with COVID-19: from the perspective of immune system 'evolution' and 'revolution'.Expert reviews in molecular medicine · 2022Review
- Human CD36Immunology · 2021Article
- Gestational Age-Specific Complete Blood Count Signatures in Necrotizing Enterocolitis.Frontiers in pediatrics · 2021Article
- BLOOD CELLS PROFILE IN UMBILICAL CORD OF LATE PRETERM AND TERM NEWBORNS.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2019Article
- Diagnostic value of eosinopenia and neutrophil to lymphocyte ratio on early onset neonatal sepsis.Korean journal of pediatrics · 2019Article
- Inherited and Environmental Factors Influence Human Monocyte Heterogeneity.Frontiers in immunology · 2019Review
- Intrinsic Maturational Neonatal Immune Deficiencies and Susceptibility to Group B Streptococcus Infection.Clinical microbiology reviews · 2017Review
- Increased monocytes and bands following a red blood cell transfusion.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Immunologic and Hematological Abnormalities in Necrotizing Enterocolitis.Clinics in perinatology · 2015Review
- Acute drop in blood monocyte count differentiates NEC from other causes of feeding intolerance.Journal of perinatology : official journal of the California Perinatal Association · 2014Article
- Blood eosinophil levels in newborns with severe indirect hyperbilirubinemia treated with phototherapy.Iranian journal of pediatrics · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBlood concentrations of eosinophils and monocytes are part of the complete blood count. Reference ranges for these concentrations during the neonatal period, established by very large sample sizes and modern methods, are needed for identifying abnormally low or high values. STUDY
designWe constructed reference ranges for eosinophils per microl and monocytes per microl among neonates of 22 to 42 weeks of gestation, on the day of birth, and also during 28 days after birth. Data were obtained from archived electronic records over an eight and one-half-year period in a multihospital health-care system. In keeping with the reference range concept, values were excluded from neonates with a diagnosis of infection or necrotizing enterocolitis (NEC).
resultEosinophils and monocytes per microl of blood were electronically retrieved from 96 162 records, of which 63 371 that lacked a diagnosis of infection or NEC were included in this reference range report. The mean value for eosinophils per microl on the day of birth increased linearly between 22 and 42 weeks of gestation, as did the 5 and 95% values. The reference range at 40 weeks was 140 to 1300 microl(-1) (mean 550 microl(-1)). Similarly, the mean value for monocytes increased linearly over this interval, with a reference range at 40 weeks of 300 to 3300 microl(-1) (mean 1400 microl(-1)). Over the first 4 weeks after birth, no appreciable change was observed in 5% limit and mean eosinophil count, with a slight increase in the 95% limit in week 4. A slight increase in monocyte count was observed during the first 2 weeks after birth.
conclusionThe results of this analysis describe reference ranges for blood concentrations of eosinophils and monocytes during the neonatal period. Additional study is needed for determining the relevance of values falling outside the reference range.
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