ArticleCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology2010
Cyclic stretch magnitude and duration affect rat alveolar epithelial gene expression.
Article in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
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Who cites it
17 citing papers in PubMed.
- HER2 Signaling Implicated in Regulating Alveolar Epithelial Permeability with Cyclic Stretch.International journal of molecular sciences · 2019Article
- Architecture-Dependent Anisotropic Hysteresis in Smooth Muscle Cells.Biophysical journal · 2018Article
- Elafin Treatment Rescues EGFR-Klf4 Signaling and Lung Cell Survival in Ventilated Newborn Mice.American journal of respiratory cell and molecular biology · 2018Article
- Regional distribution of transpulmonary pressure.Annals of translational medicine · 2018Review
- Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.Respiratory research · 2018Article
- Article
- Integrated Stress Response Mediates Epithelial Injury in Mechanical Ventilation.American journal of respiratory cell and molecular biology · 2017Article
- Variable ventilation improves pulmonary function and reduces lung damage without increasing bacterial translocation in a rat model of experimental pneumonia.Respiratory research · 2016Article
- Ventilation-induced increases in EGFR ligand mRNA are not altered by intra-amniotic LPS or ureaplasma in preterm lambs.PloS one · 2014Article
- Article
- Cyclic stretch-induced oxidative stress increases pulmonary alveolar epithelial permeability.American journal of respiratory cell and molecular biology · 2013Article
- Interfacial stress affects rat alveolar type II cell signaling and gene expression.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- MicroRNA modulate alveolar epithelial response to cyclic stretch.BMC genomics · 2012Article
- Stop the flow: a paradigm for cell signaling mediated by reactive oxygen species in the pulmonary endothelium.Annual review of physiology · 2012Review
- Mechanobiology in lung epithelial cells: measurements, perturbations, and responses.Comprehensive Physiology · 2012Review
- WNT/β-catenin signaling is modulated by mechanical ventilation in an experimental model of acute lung injury.Intensive care medicine · 2011Article
- Role of airway recruitment and derecruitment in lung injury.Critical reviews in biomedical engineering · 2011Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Mechanical ventilation with large tidal volumes can increase lung alveolar permeability and initiate inflammatory responses; but the mechanisms that regulate ventilator-associated lung injury and inflammation remain unclear. Analysis of the genomic response of the lung has been performed in intact lungs ventilated at large tidal volumes. This study is the first to study the genomic response of cultured primary alveolar epithelial cells undergoing large and moderate physiologic cyclic stretch. Responses were dependent on stretch magnitude and duration. Genomic expression was validated for 5 genes of interest: Amphiregulin, Glutamate-Cysteine Ligase Catalytic subunit, Matrix Metalloproteinase 7, Protein Phosphatase 1 regulatory inhibitor subunit 10, and Serpine-1, and protein expression mirrored genomic responses. Differences between results reported from homogenized intact lungs and monolayers of alveolar epithelial cells with type-I like phenotype provide provocative evidence that the whole lung preparation may mask the response of individual cell types.
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Registered trials
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