ArticleCarcinogenesis2010
Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes.
Article in Carcinogenesis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Association between HSD17B1 rs605059 polymorphisms and the risk of uterine diseases: a systemic review and meta-analysis.International journal of clinical and experimental pathology · 2015Pooled it
- Eight functional polymorphisms in the estrogen receptor 1 gene and endometrial cancer risk: a meta-analysis.PloS one · 2013Pooled it
- Progressions of the correlation between lipid metabolism and immune infiltration characteristics in gastric cancer and identification of BCHE as a potential biomarker.Frontiers in immunology · 2024Article
- TransOrGAN: An Artificial Intelligence Mapping of Rat Transcriptomic Profiles between Organs, Ages, and Sexes.Chemical research in toxicology · 2023Article
- Molecular Regulation of Androgen Receptors in Major Female Reproductive System Cancers.International journal of molecular sciences · 2022Review
- Lipid Metabolic-Related Signature CYP19A1 is a Potential Biomarker for Prognosis and Immune Cell Infiltration in Gastric Cancer.Journal of inflammation research · 2022Article
- Using BioPAX-Parser (BiP) to enrich lists of genes or proteins with pathway data.BMC bioinformatics · 2021Article
- The impact of CYP19A1 variants and haplotypes on breast cancer risk, clinicopathological features and prognosis.Molecular genetics & genomic medicine · 2021Article
- Endometrial cancer: a genetic point of view.Translational cancer research · 2020Article
- Kaempferol, a natural dietary flavonoid, suppresses 17β-estradiol-induced survivin expression and causes apoptotic cell death in endometrial cancer.Oncology letters · 2018Article
- Article
- Sex Steroid Hormone Single-Nucleotide Polymorphisms, Pesticide Use, and the Risk of Prostate Cancer: A Nested Case-Control Study within the Agricultural Health Study.Frontiers in oncology · 2016Article
- Article
- Genetic variants in sex hormone metabolic pathway genes and risk of esophageal squamous cell carcinoma.Carcinogenesis · 2013Article
- Common genetic variants in the 9p21 region and their associations with multiple tumours.British journal of cancer · 2013Article
- Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States.Molecular vision · 2013Article
- Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer.Cancer epidemiology · 2012Article
- Common genetic variants in sex hormone pathway genes and papillary thyroid cancer risk.Thyroid : official journal of the American Thyroid Association · 2012Article
- Article
- Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes.Fertility and sterility · 2011Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundEstrogen plays a major role in endometrial carcinogenesis, suggesting that common variants of genes in the sex hormone metabolic pathway may be related to endometrial cancer risk. In support of this view, variants in CYP19A1 [cytochrome P450 (CYP), family 19, subfamily A, polypeptide 1] have been associated with both circulating estrogen levels and endometrial cancer risk. Associations with variants in other genes have been suggested, but findings have been inconsistent.
methodsWe examined 36 sex hormone-related genes using a tagging approach in a population-based case-control study of 417 endometrial cancer cases and 407 controls conducted in Poland. We evaluated common variation in these genes in relation to endometrial cancer risk using sequential haplotype scan, variable-sized sliding window and adaptive rank-truncated product (ARTP) methods.
resultsIn our case-control study, the strongest association with endometrial cancer risk was for AR (androgen receptor; ARTP P = 0.006). Multilocus analyses also identified boundaries for a region of interest in AR and in CYP19A1 around a previously identified susceptibility loci. We did not find evidence for consistent associations between previously reported candidate single-nucleotide polymorphisms in this pathway and endometrial cancer risk. DISCUSSION: In summary, we identified regions in AR and CYP19A1 that are of interest for further evaluation in relation to endometrial cancer risk in future haplotype and subsequent fine mapping studies in larger study populations.
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