ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Normal hearing is required for the emergence of long-lasting inhibitory potentiation in cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Hearing and early life adversity: effects of developmental stress on sensory processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Advances in the Electrophysiological Recordings of Long-Term Potentiation.International journal of molecular sciences · 2023Review
- A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Editorial: Neuromodulatory Function in Auditory Processing.Frontiers in neural circuits · 2022Article
- Age-related hearing loss pertaining to potassium ion channels in the cochlea and auditory pathway.Pflugers Archiv : European journal of physiology · 2021Review
- Deletion of BDNF in Pax2 Lineage-Derived Interneuron Precursors in the Hindbrain Hampers the Proportion of Excitation/Inhibition, Learning, and Behavior.Frontiers in molecular neuroscience · 2021Article
- Disturbed Balance of Inhibitory Signaling Links Hearing Loss and Cognition.Frontiers in neural circuits · 2021Article
- The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Inhibitory Plasticity: From Molecules to Computation and Beyond.International journal of molecular sciences · 2020Review
- Stability in the Face of Change: Lifelong Experience-Dependent Plasticity in the Sensory Cortex.Frontiers in cellular neuroscience · 2020Article
- Transcutaneous Osseointegrated Implants for Pediatric Patients With Aural Atresia.JAMA otolaryngology-- head & neck surgery · 2018Article
- Auditory deprivation modifies the expression of brain-derived neurotrophic factor and tropomyosin receptor kinase B in the rat auditory cortex.Journal of otology · 2017Article
- BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury.Molecular neurobiology · 2016Article
- Conductive Hearing Loss Has Long-Lasting Structural and Molecular Effects on Presynaptic and Postsynaptic Structures of Auditory Nerve Synapses in the Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Specific synaptopathies diversify brain responses and hearing disorders: you lose the gain from early life.Cell and tissue research · 2015Review
- α4βδ-GABAARs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia.Neuroscience · 2014Article
- A sensitive period for the impact of hearing loss on auditory perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Perception of binaural cues develops in children who are deaf through bilateral cochlear implantation.PloS one · 2014Article
- Auditory training during development mitigates a hearing loss-induced perceptual deficit.Frontiers in systems neuroscience · 2014Article
- GABAergic synapses: their plasticity and role in sensory cortex.Frontiers in cellular neuroscience · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Long-term synaptic plasticity is a putative mechanism for learning in adults. However, there is little understanding of how synaptic plasticity mechanisms develop or whether their maturation depends on experience. Since inhibitory synapses are particularly malleable to sensory stimulation, long-lasting potentiation of inhibitory synapses was characterized in auditory thalamocortical slices. Intracortical high-frequency electrical stimulation led to a 67% increase in inhibitory synaptic currents. In the absence of stimulation, inhibitory potentiation was induced by a brief exposure to exogenous brain-derived neurotrophic factor (BDNF). BDNF exposure occluded any additional potentiation by high-frequency afferent stimulation, suggesting that BDNF signaling is sufficient to account for inhibitory potentiation. Moreover, inhibitory potentiation was reduced significantly by extracellular application of a BDNF scavenger or by intracellular blockade of BDNF receptor [tropomyosin-related kinase B (TrkB)] signaling. In contrast, glutamatergic or GABAergic antagonists did not prevent the induction of inhibitory potentiation. Since BDNF and TrkB expression are influenced strongly by activity, we predicted that inhibitory potentiation would be diminished by manipulations that decrease central auditory activity, such as hearing loss. Two forms of hearing loss were examined: conductive hearing loss in which the cochleae are not damaged or sensorineural hearing loss in which both cochleae are removed. Both forms of hearing loss were found to reduce significantly the magnitude of inhibitory potentiation. These data indicate that early experience is necessary for the normal development of BDNF-mediated long-lasting inhibitory potentiation, which may be associated with perceptual deficits at later ages.
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