ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Gain control in CA1 pyramidal cells using changes in somatic conductance.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Complex excitability and "flipping" of granule cells: An experimental and computational study.PloS one · 2026Article
- A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics.eLife · 2023Article
- Article
- [Comparison of electrophysiological properties of parvalbumin neurons in the tail of the striatum and the auditory cortex of mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Physiological noise facilitates multiplexed coding of vibrotactile-like signals in somatosensory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Spike threshold dynamics in spinal motoneurons during scratching and swimming.The Journal of physiology · 2017Article
- Competition between Persistent NaFrontiers in cellular neuroscience · 2017Article
- Gain Modulation of Cholinergic Neurons in the Medial Septum-Diagonal Band of Broca Through Hyperpolarization.Hippocampus · 2016Article
- Implications of cellular models of dopamine neurons for disease.Journal of neurophysiology · 2016Review
- Regulation of Cortical Dynamic Range by Background Synaptic Noise and Feedforward Inhibition.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo.Journal of visualized experiments : JoVE · 2016Article
- Enhanced Sensitivity to Rapid Input Fluctuations by Nonlinear Threshold Dynamics in Neocortical Pyramidal Neurons.PLoS computational biology · 2016Article
- The domain of neuronal firing on a plane of input current and conductance.Journal of computational neuroscience · 2015Article
- Non-linear Membrane Properties in Entorhinal Cortical Stellate Cells Reduce Modulation of Input-Output Responses by Voltage Fluctuations.PLoS computational biology · 2015Article
- Mechanisms of gain control by voltage-gated channels in intrinsically-firing neurons.PloS one · 2015Article
- Mathematical analysis of depolarization block mediated by slow inactivation of fast sodium channels in midbrain dopamine neurons.Journal of neurophysiology · 2014Article
- A simple Markov model of sodium channels with a dynamic threshold.Journal of computational neuroscience · 2014Article
- Development of dendritic tonic GABAergic inhibition regulates excitability and plasticity in CA1 pyramidal neurons.Journal of neurophysiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Gain modulation is an important feature of neural activity. Previous work has focused on the ability of background synaptic noise to modulate the slope (i.e., gain) of the frequency-current (f-I) relationship in neurons. To date, demonstrations of gain control that are independent of synaptic noise have been limited. We investigated the effects of increasing somatic conductance in the form of tonic inhibition on the initial and steady-state f-I relationship of CA1 pyramidal cells. We find that increasing membrane conductance reduces the gain of the steady-state f-I relationship through a graded increase in the magnitude of spike frequency adaptation. Increased adaptation arises through a conductance-induced depolarization of spike voltage threshold. Thus, by increasing the magnitude of spike frequency adaptation, added conductance can reduce the gain of the steady-state f-I relationship in the absence of random background membrane fluctuations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.