ArticleSchizophrenia bulletin2011
Neuropsychological profiles in different at-risk states of psychosis: executive control impairment in the early--and additional memory dysfunction in the late--prodromal state.
Article in Schizophrenia bulletin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- Longitudinal change in neurocognitive functioning in children and adolescents at clinical high risk for psychosis: a systematic review.European child & adolescent psychiatry · 2024Pooled it
- Trial
- Increased intra-individual variability of cognitive processing in subjects at risk mental state and schizophrenia patients.PloS one · 2013Trial
- Cognitive predictors of transition and remission of psychosis risk syndrome in a child and adolescent sample: longitudinal findings from the CAPRIS study.European child & adolescent psychiatry · 2024Article
- Neurocognitive Deficits in First-Episode and Chronic Psychotic Disorders: A Systematic Review from 2009 to 2022.Brain sciences · 2023Review
- Neurocognition and functioning in adolescents at clinical high risk for psychosis.Child and adolescent psychiatry and mental health · 2023Article
- Cognitive Dysfunction as a Risk Factor for Psychosis.Current topics in behavioral neurosciences · 2023Article
- Associations between symptom and neurocognitive dimensions in clinical high risk for psychosis.Schizophrenia research. Cognition · 2022Article
- Dissociable impairments of verbal learning differentiate childhood risk profiles for schizophrenia.Schizophrenia research. Cognition · 2022Article
- Characterising cognitive heterogeneity in individuals at clinical high-risk for psychosis: a cluster analysis with clinical and functional outcome prediction.European archives of psychiatry and clinical neuroscience · 2022Article
- Cognitive predictors of longitudinal positive symptom course in clinical high risk for psychosis.Schizophrenia research. Cognition · 2021Article
- Generalized neurocognitive impairment in individuals at ultra-high risk for psychosis: The possible key role of slowed processing speed.Brain and behavior · 2021Article
- Sleep, sleep spindles, and cognitive functions in drug-naive patients with first-episode psychosis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Memory Impairments and Psychosis Prediction: A Scoping Review and Theoretical Overview.Neuropsychology review · 2020Article
- Neuropsychological profile of children and adolescents with psychosis risk syndrome: the CAPRIS study.European child & adolescent psychiatry · 2020Article
- Neuropsychological, clinical and environmental predictors of severe mental disorders in offspring of patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2020Observational
- Neuropsychological deficits in participants at clinical high risk for psychosis recruited from the community: relationships to functioning and clinical symptoms.Psychological medicine · 2020Article
- Antisaccade and prosaccade eye movements in individuals clinically at risk for psychosis: comparison with first-episode schizophrenia and prediction of conversion.European archives of psychiatry and clinical neuroscience · 2019Article
- Saccadic eye movements in different dimensions of schizophrenia and in clinical high-risk state for psychosis.BMC psychiatry · 2019Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impairments in neuropsychological functioning have been described in subjects clinically at high risk for psychosis, but the specific cognitive deficits in different clinical high-risk groups remain to be elucidated. The German Research Network on Schizophrenia employs a heuristic 2-stage model: a putatively late prodromal state (LPS), characterized by the onset of attenuated positive or brief psychotic symptoms, and an early prodromal state (EPS), mainly characterized by the presence of basic symptoms, which are predictive for psychosis within the next 10 years. A total of 205 subjects met the criteria for either an EPS or an LPS of psychosis and were assessed with a comprehensive neuropsychological test battery. Neurocognitive profiles of high-risk groups were compared with data of 87 healthy controls comparable with regard to gender, age, and premorbid verbal IQ. Patients in the LPS were impaired in all neurocognitive domains (memory/learning, executive control/processing speed, and working memory) examined, with memory being the worst. Deficits were less pronounced in patients in the EPS, with a specific deficit in the executive control/processing speed domain. Consistent with a progressive neurodevelopmental disorder, some cognitive abilities were already impaired in patients in the EPS, followed by further deterioration in the LPS. Specifically, deficits in executive control functioning were related to the presence of basic symptoms, indicating a vulnerability for psychosis. Memory deficits were associated with the onset of psychotic symptoms indicating further disease progression in the trajectory to psychosis and, thus, may be useful in predicting psychosis and targeting early intervention.
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