ReviewCell calcium2010
Aberrant Ca2+ handling in lysosomal storage disorders.
Review in Cell calcium, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Epigenetic and Metabolic Regulation of Macrophages during Gout.Gout, urate, and crystal deposition disease · 2023Article
- TRPML1-Induced Lysosomal CaInternational journal of molecular sciences · 2023Article
- Lysosomal Potassium Channels.Handbook of experimental pharmacology · 2023Review
- TPC Functions in the Immune System.Handbook of experimental pharmacology · 2023Article
- Intracellular CaFrontiers in physiology · 2023Review
- The evolution of organellar calcium mapping technologies.Cell calcium · 2022Review
- TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann-Pick type C1, and Batten disease.EMBO molecular medicine · 2022Article
- The CACNA1A Mutant Disrupts Lysosome Calcium Homeostasis in Cerebellar Neurons and the Resulting Endo-Lysosomal Fusion Defect Can be Improved by Calcium Modulation.Neurochemical research · 2022Article
- Association Between Gray Matter Volume Variations and Energy Utilization in the Brain: Implications for Developmental Stuttering.Journal of speech, language, and hearing research : JSLHR · 2021Article
- Review
- Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis.Autophagy · 2021Article
- The Resurrection of Phenotypic Drug Discovery.ACS medicinal chemistry letters · 2020Article
- Novel compounds that reverse the disease phenotype in Type 2 Gaucher disease patient-derived cells.Bioorganic & medicinal chemistry letters · 2020Article
- Patient-Derived Phenotypic High-Throughput Assay to Identify Small Molecules Restoring Lysosomal Function in Tay-Sachs Disease.SLAS discovery : advancing life sciences R & D · 2019Article
- Release and uptake mechanisms of vesicular CaProtein & cell · 2019Review
- Niemann-Pick type C disease: The atypical sphingolipidosis.Advances in biological regulation · 2018Review
- Dysregulation of autophagy as a common mechanism in lysosomal storage diseases.Essays in biochemistry · 2017Review
- A voltage-dependent KThe Journal of cell biology · 2017Article
- TFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entry.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Lysosomal storage diseases (LSDs) are caused by inability of cells to process the material captured during endocytosis. While they are essentially diseases of cellular "indigestion", LSDs affect large number of cellular activities and, as such, they teach us about the integrative function of the cell, as well as about the gaps in our knowledge of the endocytic pathway and membrane transport. The present review summarizes recent findings on Ca2+ handling in LSDs and attempts to identify the key questions on alterations in Ca2+ signaling and membrane transport in this group of diseases, answers to which may lie in delineating the cellular pathogeneses of LSDs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.