ArticleNeuroImage2010
Neural response to working memory load varies by dopamine transporter genotype in children.
Article in NeuroImage, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03407729 (Structure & Function of Dopaminergic Brain Networks Following Postnatally-Occurring Hypoxic Insults), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Structure & Function of Dopaminergic Brain Networks Following Postnatally-Occurring Hypoxic Insults
Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Preventing academic difficulties in preterm children: a randomised controlled trial of an adaptive working memory training intervention - IMPRINT study.BMC pediatrics · 2013Trial
- Tandem repeats in human brain evolution and disease susceptibility.Molecules and cells · 2026Review
- Cognitive Control.Annual review of psychology · 2025Review
- Article
- Abnormal functional connectivities patterns of multidomain cognitive impairments in pontine stroke patients.Human brain mapping · 2022Article
- Researching Mitigation of Alcohol Binge Drinking in Polydrug Abuse: KCNK13 and RASGRF2 Gene(s) Risk Polymorphisms Coupled with Genetic Addiction Risk Severity (GARS) Guiding Precision Pro-Dopamine Regulation.Journal of personalized medicine · 2022Article
- The Role of Dopaminergic Genes in Probabilistic Reinforcement Learning in Schizophrenia Spectrum Disorders.Brain sciences · 2021Article
- The maturation and cognitive relevance of structural brain network organization from early infancy to childhood.NeuroImage · 2021Article
- Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder.Translational psychiatry · 2021Review
- Convergent neural substrates of inattention in bipolar disorder patients and dopamine transporter-deficient mice using the 5-choice CPT.Bipolar disorders · 2020Article
- Interaction between striatal volume and DAT1 polymorphism predicts working memory development during adolescence.Developmental cognitive neuroscience · 2018Article
- Imaging genetics in neurodevelopmental psychopathology.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Genome-wide association study of working memory brain activation.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- Atypical spatiotemporal signatures of working memory brain processes in autism.Translational psychiatry · 2015Article
- Indirect association of DAT1 genotype with executive function through white matter volume in orbitofrontal cortex.Psychiatry research · 2015Article
- Resting-state striato-frontal functional connectivity is sensitive to DAT1 genotype and predicts executive function.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Applying imaging genetics to ADHD: the promises and the challenges.Molecular neurobiology · 2014Review
- Preliminary investigation of the influence of dopamine regulating genes on social working memory.Social neuroscience · 2014Article
- Individual differences in emotion-cognition interactions: emotional valence interacts with serotonin transporter genotype to influence brain systems involved in emotional reactivity and cognitive control.Frontiers in human neuroscience · 2013Article
- Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning.European archives of psychiatry and clinical neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Inheriting two (10/10) relative to one (9/10) copy of the 10-repeat allele of the dopamine transporter genotype (DAT1) is associated with Attention Deficit Hyperactivity Disorder, a childhood disorder marked by poor executive function. We examined whether functional anatomy underlying working memory, a component process of executive function, differed by DAT1 in 7-12 year-old typically developing children. 10/10 and 9/10 carriers performed a verbal n-back task in two functional magnetic resonance imaging (fMRI) runs varying in working memory load, high (2-back vs. 1-back) and low (1-back vs. 0-back). Performance accuracy was superior in 9/10 than 10/10 carriers in the high but not low load runs. Examination of each run separately revealed that frontal-striatal-parietal regions were more activated in 9/10 than 10/10 carriers in the high load run; the groups did not differ in the low load run. Examination of load effects revealed a DAT1xLoad interaction in the right hemisphere in the caudate, our a priori region of interest. Exploratory analysis at a more liberal threshold revealed this interaction in other basal ganglia regions (putamen, and substantial nigra/subthalamic nuclei - SN/STN) and in medial parietal cortex (left precuneus). The striatal and parietal regions were more activated in 9/10 carriers under high than low load, and DAT1 differences (9/10>10/10) were evident only under high load. In contrast, SN/STN tended to be more activated in 10/10 carriers under low than high load and DAT1 differences (10/10>9/10) were evident only under low load. Thus, 10-repeat homozygosity of DAT1 was associated with reduced performance and a lack of increased basal ganglia involvement under higher working memory demands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.