ReviewGenome biology2009
The PIN-FORMED (PIN) protein family of auxin transporters.
Review in Genome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 220 papers, 1 of them a synthesis that pooled it.
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Who cites it
220 citing papers in PubMed, 1 synthesis or guideline pooled it, 511 citations in OpenAlex.
- Meta-analysis of RNA-Seq studies reveals genes with dominant functions during flower bud endo- to eco-dormancy transition in Prunus species.Scientific reports · 2021Pooled it
- Different Dynamics:Biology · 2026Article
- Bacillus cereus T146 Enhances Wheat Salt Tolerance by Restructuring the Rhizosphere Microbiome and Activating TaPIN1-Dependent Auxin Transport.Plant, cell & environment · 2026Article
- Quantitative trait loci analysis identifying novel genomic regions for off-target dicamba tolerance in soybean [Glycine max (L.) Merr.].BMC plant biology · 2026Article
- Reducing recalcitrance of black pepper toHorticulture research · 2026Article
- Tailored for swift recognition: A structural perspective on secondary active plant hormone transporters.The Plant journal : for cell and molecular biology · 2026Review
- Integrated Multi-Omics Analysis Revealed the Synergistic Regulatory Mechanisms of Salt Tolerance in Soybean (Kefeng 1).Plants (Basel, Switzerland) · 2026Article
- Genome-wide association study for root-related traits at vegetative growth stages of soybean (Glycine max L. Merrill).BMC genomics · 2026Article
- Differential Alteration of Gene Expression by Benzyl Adenine andPlants (Basel, Switzerland) · 2025Article
- Identification of Auxin, Cytokinin, Transcription Factors, and Other Zygotic Embryogenesis-Related Genes inPlants (Basel, Switzerland) · 2025Article
- PtrSAUR32 Interacts with PtrPP2C.Ds to Regulate Root Growth in Citrus.Plants (Basel, Switzerland) · 2025Article
- ThePlants (Basel, Switzerland) · 2025Article
- Cellular and physiological functions of SGR family in gravitropic response in higher plants.Journal of advanced research · 2025Review
- Involvement of endogenous IAA and ABA in the regulation of arbuscular mycorrhizal fungus on rooting of tea plant (Camellia sinensis L.) cuttings.BMC plant biology · 2024Article
- Cellular mechanism of polarized auxin transport on fruit shape determination revealed by time-lapse live imaging.Plant reproduction · 2024Article
- Functional Analysis ofInternational journal of molecular sciences · 2024Article
- Identification of PotatoInternational journal of molecular sciences · 2024Article
- Auxin-Mediated Lateral Root Development in Root Galls of Cucumber underPlants (Basel, Switzerland) · 2024Article
- Single-cell transcriptome atlases of soybean root and mature nodule reveal new regulatory programs that control the nodulation process.Plant communications · 2024Article
- Development of pollinated and unpollinated ovules in Ginkgo biloba: unravelling the role of pollen in ovule tissue maturation.Journal of experimental botany · 2024Article
160 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The PIN-FORMED (PIN) proteins are secondary transporters acting in the efflux of the plant signal molecule auxin from cells. They are asymmetrically localized within cells and their polarity determines the directionality of intercellular auxin flow. PIN genes are found exclusively in the genomes of multicellular plants and play an important role in regulating asymmetric auxin distribution in multiple developmental processes, including embryogenesis, organogenesis, tissue differentiation and tropic responses. All PIN proteins have a similar structure with amino- and carboxy-terminal hydrophobic, membrane-spanning domains separated by a central hydrophilic domain. The structure of the hydrophobic domains is well conserved. The hydrophilic domain is more divergent and it determines eight groups within the protein family. The activity of PIN proteins is regulated at multiple levels, including transcription, protein stability, subcellular localization and transport activity. Different endogenous and environmental signals can modulate PIN activity and thus modulate auxin-distribution-dependent development. A large group of PIN proteins, including the most ancient members known from mosses, localize to the endoplasmic reticulum and they regulate the subcellular compartmentalization of auxin and thus auxin metabolism. Further work is needed to establish the physiological importance of this unexpected mode of auxin homeostasis regulation. Furthermore, the evolution of PIN-based transport, PIN protein structure and more detailed biochemical characterization of the transport function are important topics for further studies.
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