Trial reportCancer2010
Impact of smoking on patients with stage III colon cancer: results from Cancer and Leukemia Group B 89803.
Trial report in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Impact of prediagnostic smoking and smoking cessation on colorectal cancer prognosis: a meta-analysis of individual patient data from cohorts within the CHANCES consortium.Annals of oncology : official journal of the European Society for Medical Oncology · 2018Pooled it
- Associations between cigarette smoking status and colon cancer prognosis among participants in North Central Cancer Treatment Group Phase III Trial N0147.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Trial
- The Association of Oxaliplatin-Containing Adjuvant Chemotherapy Duration with Overall and Cancer-Specific Mortality in Individuals with Stage III Colon Cancer: A Population-Based Retrospective Cohort Study.Current oncology (Toronto, Ont.) · 2023Article
- Association of Inflammatory Biomarkers With Survival Among Patients With Stage III Colon Cancer.JAMA oncology · 2023Article
- Long-term follow-up of smokers following lung and colorectal cancer diagnosis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Diet- and Lifestyle-Based Prediction Models to Estimate Cancer Recurrence and Death in Patients With Stage III Colon Cancer (CALGB 89803/Alliance).Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Article
- Body Mass Index and Other Risk Factors Effects on Colon Cancer Prognosis in Pakistan.Journal of cancer & allied specialties · 2022Article
- Smoking Behavior and Prognosis After Colorectal Cancer Diagnosis: A Pooled Analysis of 11 Studies.JNCI cancer spectrum · 2021Article
- The effect of smoking, obesity and diabetes on recurrence-free and overall survival in patients with stage III colon cancer receiving adjuvant chemotherapy.Cancer reports (Hoboken, N.J.) · 2021Article
- Article
- Smoking Status at Diagnosis and Colorectal Cancer Prognosis According to Tumor Lymphocytic Reaction.JNCI cancer spectrum · 2020Article
- Prognostic value of postoperative serum carcinoembryonic antigen levels in colorectal cancer patients who smoke.PloS one · 2020Article
- Smoking Status and Survival Among a National Cohort of Lung and Colorectal Cancer Patients.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Association between Dietary and Lifestyle Indices and Colorectal Cancer in Oman: A Case-Control StudyAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Lifestyle after Colorectal Cancer Diagnosis in Relation to Survival and Recurrence: A Review of the Literature.Current colorectal cancer reports · 2017Review
- Factors associated with short recurrence-free survival in completely resected colon cancer.Journal of community hospital internal medicine perspectives · 2017Article
- Increased chemoresistance via Snail-Raf kinase inhibitor protein signaling in colorectal cancer in response to a nicotine derivative.Oncotarget · 2016Article
- Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-Analysis.Gastroenterology research and practice · 2016Review
- Availability of Information About Lifestyle for Cancer Survivors in England: A Review of Statutory and Charitable Sector Organizations and Cancer Centers.JMIR cancer · 2015Article
- The biological and clinical effects of smoking by patients with cancer and strategies to implement evidence-based tobacco cessation support.The Lancet. Oncology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundCigarette smoking has been shown to increase the risk of developing colorectal cancer, particularly smoking early in life. Little is known about the impact of tobacco use on colon cancer recurrence among colon cancer survivors.
methodsThe authors prospectively collected lifetime smoking history from stage III colon cancer patients enrolled in a phase 3 trial via self-report questionnaires during and 6 months after completion of adjuvant chemotherapy. Smoking status was defined as never, current, or past. Lifetime pack-years were defined as number of lifetime packs of cigarettes. Patients were followed for recurrence or death.
resultsData on smoking history were captured on 1045 patients with stage III colon cancer receiving adjuvant therapy (46% never smokers; 44% past; 10% current). The adjusted hazard ratio (HR) for disease-free survival (DFS) was 0.99 (95% confidence interval [CI], 0.70-1.41), 1.17 (95% CI 0.89-1.55), and 1.22 (95% CI 0.92-1.61) for lifetime pack-years 0-10, 10-20, and 20+, respectively, compared with never smoking (P = .16). In a preplanned exploratory analysis of smoking intensity early in life, the adjusted HR for 12+ pack-years before age 30 years for DFS was 1.37 (95% CI, 1.02-1.84) compared with never smoking (P = .04). The adjusted HR for DFS was 1.18 (95% CI, 0.92-1.50) for past smokers and 1.10 (95% CI, 0.73-1.64) for current smokers, compared with never smokers.
conclusionsTotal tobacco usage early in life may be an important, independent prognostic factor of cancer recurrences and mortality in patients with stage III colon cancer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.