ReviewEuropean journal of applied physiology2010
A definition of normovolaemia and consequences for cardiovascular control during orthostatic and environmental stress.
Review in European journal of applied physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight.Nature reviews. Cardiology · 2024Review
- Central Hypovolemia Detection During Environmental Stress-A Role for Artificial Intelligence?Frontiers in physiology · 2021Review
- Changes in Arterial Blood Pressure and Oxygen Tension as a Result of Hoisting in Isoflurane Anesthetized Healthy Adult Horses.Frontiers in veterinary science · 2020Article
- The influence of microgravity on cerebral blood flow and electrocortical activity.Experimental brain research · 2019Article
- The pathophysiology of the vasovagal response.Heart rhythm · 2018Review
- Factors associated with residual urine volume preservation in patients undergoing hemodialysis for end-stage kidney disease in Kinshasa.BMC nephrology · 2018Article
- Support Vector Machine Based Monitoring of Cardio-Cerebrovascular Reserve during Simulated Hemorrhage.Frontiers in physiology · 2017Article
- Cardiovascular Response Patterns to Sympathetic Stimulation by Central Hypovolemia.Frontiers in physiology · 2016Article
- Hypovolemia explains the reduced stroke volume at altitude.Physiological reports · 2013Article
- Noninvasive continuous hemodynamic monitoring.Journal of clinical monitoring and computing · 2012Review
- NT-ProBNP levels, water and sodium homeostasis in healthy men: effects of 7 days of dry immersion.European journal of applied physiology · 2011Article
- Gravity, the hydrostatic indifference concept and the cardiovascular system.European journal of applied physiology · 2011Review
- Reduced cardiac contractile force due to sympathovagal dysfunction mediates the additive hypotensive effects of limited-access regimens of ethanol and clonidine in spontaneously hypertensive rats.The Journal of pharmacology and experimental therapeutics · 2010Article
- Effect of volume loading on the Frank-Starling relation during reductions in central blood volume in heat-stressed humans.The Journal of physiology · 2010Article
- Central and cerebrovascular effects of leg crossing in humans with sympathetic failure.Clinical science (London, England : 1979) · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Frank-Starling mechanism describes the relationship between stroke volume and preload to the heart, or the volume of blood that is available to the heart--the central blood volume. Understanding the role of the central blood volume for cardiovascular control has been complicated by the fact that a given central blood volume may be associated with markedly different central vascular pressures. The central blood volume varies with posture and, consequently, stroke volume and cardiac output (Q) are affected, but with the increased central blood volume during head-down tilt, stroke volume and Q do not increase further indicating that in the supine resting position the heart operates on the plateau of the Frank-Starling curve which, therefore, may be taken as a functional definition of normovolaemia. Since the capacity of the vascular system surpasses the blood volume, orthostatic and environmental stress including bed rest/microgravity, exercise and training, thermal loading, illness, and trauma/haemorrhage is likely to restrict venous return and Q. Consequently the cardiovascular responses are determined primarily by their effect on the central blood volume. Thus during environmental stress, flow redistribution becomes dependent on sympathetic activation affecting not only skin and splanchnic blood flow, but also flow to skeletal muscles and the brain. This review addresses the hypothesis that deviations from normovolaemia significantly influence these cardiovascular responses.
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