ArticleCommunications in statistics: theory and methods2009
Modeling Informatively Missing Genotypes in Haplotype Analysis.
Article in Communications in statistics: theory and methods, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Reducing bias of allele frequency estimates by modeling SNP genotype data with informative missingness.Frontiers in genetics · 2012Article
- A powerful test of parent-of-origin effects for quantitative traits using haplotypes.PloS one · 2011Article
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Authors and funding
3 authors.
Funding
Abstract
It is common to have missing genotypes in practical genetic studies. The majority of the existing statistical methods, including those on haplotype analysis, assume that genotypes are missing at random-that is, at a given marker, different genotypes and different alleles are missing with the same probability. In our previous work, we have demonstrated that the violation of this assumption may lead to serious bias in haplotype frequency estimates and haplotype association analysis. We have proposed a general missing data model to simultaneously characterize missing data patterns across a set of two or more biallelic markers. We have proved that haplotype frequencies and missing data probabilities are identifiable if and only if there is linkage disequilibrium between these markers under the general missing data model. In this study, we extend our work to multi-allelic markers and observe a similar finding. Simulation studies on the analysis of haplotypes consisting of two markers illustrate that our proposed model can reduce the bias for haplotype frequency estimates due to incorrect assumptions on the missing data mechanism. Finally, we illustrate the utilities of our method through its application to a real data set from a study of scleroderma.
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Registered trials
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