Evidence map›Paper›PMID 20051984›Full record

ReviewNature reviews. Genetics2010

Genetics of mammalian meiosis: regulation, dynamics and impact on fertility.

Mary Ann Handel, John C Schimenti

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 336 papers.

0numbers the graph read from it
0cells of the map it votes in
336citing papers in PubMed
50.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

336 citing papers in PubMed, 572 citations in OpenAlex.

  1. Article
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  11. MCT1 governs a metabolic checkpoint at pachytene during spermatogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  12. Review
  13. Article
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  15. Review
  16. Programmed meiotic errors facilitate dichotomous sperm production in the silkworm,Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  17. Article
  18. The DNA mismatch repair protein Msh4 is essential for meiosis of male but not for female in zebrafish.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026
    Article
  19. Article
  20. Article

276 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mary Ann HandelThe Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. maryann.handel@jax.org
John C Schimenti
Jackson Laboratory · USNew York State College of Veterinary Medicine · US

Funding

THE ROLE OF BRWD1 AND ITS PARALOGS IN SPERMIOGENESISP01HD042137 · NICHD · JACKSON LABORATORY · PI HANDEL, MARY ANN · 2002 to 2012
$10.3M
NICHD NIH HHS P01 HD042137
6 · The paper itself

Abstract

Meiosis is an essential stage in gamete formation in all sexually reproducing organisms. Studies of mutations in model organisms and of human haplotype patterns are leading to a clearer understanding of how meiosis has adapted from yeast to humans, the genes that control the dynamics of chromosomes during meiosis, and how meiosis is tied to gametic success. Genetic disruptions and meiotic errors have important roles in infertility and the aetiology of developmental defects, especially aneuploidy. An understanding of the regulation of meiosis, coupled with advances in genomics, may ultimately allow us to diagnose the causes of meiosis-based infertilities, more wisely apply assisted reproductive technologies, and derive functional germ cells.

Indexed as

AnimalsCrossing Over, GeneticFertilityGerm CellsHumansMammalsMeiosisModels, Genetic

Identifiers

PMID20051984
OpenAlexW2067338267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.