Evidence map›Paper›PMID 20051982›Full record

ReviewNature structural & molecular biology2010

MicroRNA assassins: factors that regulate the disappearance of miRNAs.

Zoya S Kai, Amy E Pasquinelli

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature structural & molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed
56.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 260 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Age and 17β-Estradiol (ENon-coding RNA · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. MicroRNAs in Ocular Infection.Microorganisms · 2019
    Review

76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Zoya S KaiDepartment of Biology, University of California, San Diego, La Jolla, California, USA.
Amy E Pasquinelli
University of California, San Diego · US

Funding

Role of Argonaute in miRNA biogenesis and functionR01GM071654 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PASQUINELLI, AMY E. · 2004 to 2017
$4.0M
NIGMS NIH HHS GM071654-01NIGMS NIH HHS R01 GM071654
6 · The paper itself

Abstract

MicroRNAs (miRNAs) control essential gene regulatory pathways in plants and animals. Serving as guides in silencing complexes, miRNAs direct Argonaute proteins to specific target messenger RNAs to repress protein expression. The mature, 22-nucleotide (nt) miRNA is the product of multiple processing steps, and recent studies have uncovered factors that directly control the stability of the functional RNA form. Although alteration of miRNA levels has been linked to numerous disease states, the mechanisms responsible for stabilized or reduced miRNA expression have been largely elusive. The discovery of specific cis-acting modifications and trans-acting proteins that affect miRNA half-life reveals new elements that contribute to the homeostasis of these vital regulatory molecules.

Indexed as

Eukaryotic Initiation FactorsExoribonucleasesGene Expression RegulationGene Regulatory NetworksKaryopherinsMicroRNAsModels, MolecularRibonuclease IIIEukaryotic Initiation FactorsExoribonucleasesKaryopherinsMicroRNAsRibonuclease III

Identifiers

PMID20051982
PMCPMC6417416
OpenAlexW1969104747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.