ArticlePublic health genomics2011
Translational research in cancer genetics: the road less traveled.
Article in Public health genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Which BRCA genetic testing programs are ready for implementation in health care? A systematic review of economic evaluations.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Pooled it
- Designing Software for Genomics Medicine Service Leaders to Engage Stakeholders.Proceedings. IEEE International Conference on Healthcare Informatics · 2023Article
- Health inequity in genomic personalized medicine in underrepresented populations: a look at the current evidence.Functional & integrative genomics · 2023Review
- Using the Homeland Security Exercise and Evaluation Program (HSEEP) Building Block Approach to Implement System Evaluation Theory (SET).The American journal of evaluation · 2021Article
- Prognostic Impact of the Combination ofJournal of neurosciences in rural practice · 2021Article
- The role of genomics in global cancer prevention.Nature reviews. Clinical oncology · 2021Review
- Sensors that Learn: The Evolution from Taste Fingerprints to Patterns of Early Disease Detection.Micromachines · 2019Review
- Leveraging Implementation Science to Address Health Disparities in Genomic Medicine: Examples from the Field.Ethnicity & disease · 2019Article
- Tracking human genes along the translational continuum.NPJ genomic medicine · 2019Article
- A systematic review of international guidelines and recommendations for the genetic screening, diagnosis, genetic counseling, and treatment ofCancer management and research · 2019Review
- Adding the Team into T1 Translational Research: A Case Study of Multidisciplinary Team Science in the Evaluation of Biomarkers of Prostate Cancer Risk and Prognosis.Clinical chemistry · 2019Article
- The current state of implementation science in genomic medicine: opportunities for improvement.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Review
- Mapping the evolving definitions of translational research.Journal of clinical and translational science · 2017Review
- Innovative Programmable Bio-Nano-Chip Digitizes Biology Using Sensors That Learn Bridging Biomarker Discovery and Clinical Implementation.Frontiers in public health · 2017Review
- Modeling timelines for translational science in cancer; the impact of technological maturation.PloS one · 2017Article
- Challenges and opportunities for translating medical microdevices: insights from the programmable bio-nano-chip.Bioanalysis · 2016Article
- Transdisciplinary translational behavioral (TDTB) research: opportunities, barriers, and innovations.Translational behavioral medicine · 2016Review
- To Share or Not to Share? A Survey of Biomedical Researchers in the U.S. Southwest, an Ethnically Diverse Region.PloS one · 2015Article
- Mapping the Ethics of Translational Genomics: Situating Return of Results and Navigating the Research-Clinical Divide.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2015Article
- What is translational genomics? An expanded research agenda for improving individual and population health.Applied & translational genomics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene discoveries in cancer have the potential for clinical and public health applications. To take advantage of such discoveries, a translational research agenda is needed to take discoveries from the bench to population health impact. To assess the current status of translational research in cancer genetics, we analyzed the extramural grant portfolio of the National Cancer Institute (NCI) from Fiscal Year 2007, as well as the cancer genetic research articles published in 2007. We classified both funded grants and publications as follows: T0 as discovery research; T1 as research to develop a candidate health application (e.g., test or therapy); T2 as research that evaluates a candidate application and develops evidence-based recommendations; T3 as research that assesses how to integrate an evidence-based recommendation into cancer care and prevention; and T4 as research that assesses health outcomes and population impact. We found that 1.8% of the grant portfolio and 0.6% of the published literature was T2 research or beyond. In addition to discovery research in cancer genetics, a translational research infrastructure is urgently needed to methodically evaluate and translate gene discoveries for cancer care and prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.