ArticleThe Journal of physiology2010
Zebrafish (Danio rerio) gill neuroepithelial cells are sensitive chemoreceptors for environmental CO2.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 112 citations in OpenAlex.
- Serotonin Signaling and Macrophage Subsets in Goldfish Gills: Unraveling the Neuroimmune Network for Gill Homeostasis.Life (Basel, Switzerland) · 2025Article
- Oxygen chemoreceptor inhibition by dopamine DThe Journal of physiology · 2025Article
- Cross-talk between tissues is critical for intergenerational acclimation to environmental change in Acanthochromis polyacanthus.Communications biology · 2024Article
- Structure and function of the larval teleost fish gill.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Review
- A survey of water chemistry used in zebrafish facilities and their effects on early zebrafish development.F1000Research · 2024Article
- Brain transcriptome of gobies inhabiting natural COEvolutionary applications · 2023Article
- Insights into the control and consequences of breathing adjustments in fishes-from larvae to adults.Frontiers in physiology · 2023Review
- Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia.Scientific reports · 2022Article
- Roles of Carbonic Anhydrases and Carbonic Anhydrase Related Proteins in Zebrafish.International journal of molecular sciences · 2022Review
- Does blood flow limit acute hypoxia performance in larval zebrafish (Danio rerio)?Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- A marine teleost, Opsanus beta, compensates acidosis in hypersaline water by HJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Hydrogen sulphide sensitivity and tolerance in genetically distinct lineages of a selfing mangrove fish (Kryptolebias marmoratus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- The role of TASK-2 channels in COAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Immunological characterization of two types of ionocytes in the inner ear epithelium of Pacific Chub Mackerel (Scomber japonicus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Common carp, Cyprinus carpio, prefer branchial ionoregulation at high feeding rates and kidney ionoregulation when food supply is limited: additional effects of cortisol and exercise.Fish physiology and biochemistry · 2020Article
- Effects of Water Acidification on Senegalese SoleFrontiers in physiology · 2020Article
- Hypoxia Tolerance in Teleosts: Implications of Cardiac Nitrosative Signals.Frontiers in physiology · 2018Review
- Characterization of ion channels and OJournal of neurophysiology · 2017Article
- Ex Vivo Measurement of Electrically Evoked Dopamine Release in Zebrafish Whole Brain.ACS chemical neuroscience · 2017Article
- Lactate provides a strong pH-independent ventilatory signal in the facultative air-breathing teleost Pangasianodon hypophthalmus.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult zebrafish exhibit hyperventilatory responses to absolute environmental CO(2) levels as low as 0.13% ( mmHg), more than an order of magnitude lower than the typical arterial levels (40 mmHg) monitored by the mammalian carotid body. The sensory basis underlying the ability of fish to detect and respond to low ambient CO(2) levels is not clear. Here, we show that the neuroepithelial cells (NECs) of the zebrafish gill, known to sense O(2) levels, also respond to low levels of CO(2). An electrophysiological characterization of this response using both current and voltage clamp protocols revealed that for increasing CO(2) levels, a background K(+) channel was inhibited, resulting in a partial pressure-dependent depolarization of the NEC. To elucidate the signalling pathway underlying K(+) channel inhibition, we used immunocytochemistry to show that these NECs express carbonic anhydrase (CA), an enzyme involved in CO(2) sensing in the mammalian carotid body. Further, the NEC response to CO(2) (magnitude of membrane depolarization and time required to achieve maximal response), under conditions of constant pH, was reduced by 50% by the CA-inhibitor acetazolamide. This suggests that the CO(2) detection mechanism involves an intracellular sensor that is responsive to the rate of acidification associated with the hydration of CO(2) and which does not require a change of extracellular pH. Because some cells that were responsive to increasing also responded to hypoxia with membrane depolarization, the present results demonstrate that a subset of the NECs in the zebrafish gill are bimodal sensors of CO(2) and O(2).
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