ArticleThe Journal of physiology2010
Firing probability and mean firing rates of human muscle vasoconstrictor neurones are elevated during chronic asphyxia.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Nasal high flow, but not supplemental OInternational journal of chronic obstructive pulmonary diseaseTrial
- Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea Coexistence: From Pathophysiology to Clinical Complications.International journal of chronic obstructive pulmonary disease · 2025Review
- Effective non-invasive ventilation reduces muscle sympathetic nerve activity in patients with stable hypercapnic COPD.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- The sympathetic nervous system in heart failure revisited.Heart failure reviews · 2024Review
- Sympathetic vascular transduction and baroreflex sensitivity in the context of severe COPD.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- An Overview of Flexible Sensors: Development, Application, and Challenges.Sensors (Basel, Switzerland) · 2023Review
- Sympathetic neural responses to sleep disorders and insufficiencies.American journal of physiology. Heart and circulatory physiology · 2022Review
- Sympathetic and Vagal Nerve Activity in COPD: Pathophysiology, Presumed Determinants and Underappreciated Therapeutic Potential.Frontiers in physiology · 2022Review
- Effect of varying chemoreflex stress on sympathetic neural recruitment strategies during apnea.Journal of neurophysiology · 2019Article
- Activity of muscle sympathetic neurons during normotensive pregnancy.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Recording sympathetic nerve activity in conscious humans and other mammals: guidelines and the road to standardization.American journal of physiology. Heart and circulatory physiology · 2017Review
- Blood Pressure Profile and Hypertensive Organ Damage in COPD Patients and Matched Controls. The RETAPOC Study.PloS one · 2016Observational
- Current Approaches to Quantifying Tonic and Reflex Autonomic Outflows Controlling Cardiovascular Function in Humans and Experimental Animals.Current hypertension reports · 2015Review
- Baroreceptor sensitivity after Valsalva maneuver in women with chronic obstructive pulmonary disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2012Article
- β-blockade: benefits beyond blood pressure reduction?Journal of clinical hypertension (Greenwich, Conn.) · 2012Review
- Firing patterns of muscle vasoconstrictor neurons in respiratory disease.Frontiers in physiology · 2012Article
- Respiratory modulation of muscle sympathetic nerve activity is not increased in essential hypertension or chronic obstructive pulmonary disease.The Journal of physiology · 2011Article
- Sympathetic overdrive in obesity involves purinergic hyperactivity in the resistance vasculature.The Journal of physiology · 2011Article
- On the number of preganglionic neurons driving human postganglionic sympathetic neurons: a comparison of modeling and empirical data.Frontiers in neuroscience · 2011Article
- Sympathetic neural activation: an ordered affair.The Journal of physiology · 2010Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated muscle sympathetic nerve activity (MSNA) features in many cardiovascular diseases, but how this sympathoexcitation is brought about differs across pathologies. Unitary recordings from post-ganglionic muscle vasoconstrictor neurones in human subjects have shown that the augmented MSNA in the obstructive sleep apnoea syndrome (OSAS) is associated with an increase in firing probability and mean firing rate, and an increase in multiple within-burst firing. Here we characterize the firing properties of muscle vasoconstrictor neurones in patients with chronic obstructive pulmonary disease (COPD), who are chronically asphyxic. We tested the hypothesis that this elevated chemical drive would shift the firing pattern from that seen in healthy subjects to that seen in OSAS. The mean firing probability (52%) and mean firing rate (0.92 Hz) of 17 muscle vasoconstrictor neurones recorded in COPD were comparable to those previously recorded in OSAS (51% and 0.96 Hz), but significantly higher than those recorded in a group of healthy subjects with high levels of resting MSNA (35% and 0.33 Hz). In COPD single neurones fired once in 63% of cardiac intervals, comparable to OSAS (59%), but significantly lower than in the healthy group (78%). Conversely, single neurones fired twice in 25% of cardiac intervals, similar to OSAS (27%), but significantly higher than in the healthy group (18%). We conclude that the chronic asphyxia associated with COPD results in an increase in the firing probability and mean firing frequency of muscle vasoconstrictor neurones and causes a shift towards multiple firing, reflecting an increase in central muscle vasoconstrictor drive.
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