ArticleEndocrinology2010
RFamide-related peptide and messenger ribonucleic acid expression in mammalian testis: association with the spermatogenic cycle.
Article in Endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 88 citations in OpenAlex.
- Review
- Effect of nourishing and purging fire Chinese herbal mixture on delaying light-induced premature puberty in rats.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Article
- Dual effects of gonadotropin-inhibitory hormone on testicular development in prepubertal Minxinan Black rabbits (Frontiers in veterinary science · 2024Article
- Acute restraint stress rapidly impacts reproductive neuroendocrinology and downstream gonad function in big brown bats (Eptesicus fuscus).The Journal of experimental biology · 2023Article
- Impact of stress on male fertility: role of gonadotropin inhibitory hormone.Frontiers in endocrinology · 2023Review
- Sexual Dimorphism in Kisspeptin Signaling.Cells · 2022Review
- RFamide peptides, the novel regulators of mammalian HPG axis: A review.Veterinary world · 2021Review
- Hindlimb unloading-induced reproductive suppression via Downregulation of hypothalamic Kiss-1 expression in adult male rats.Reproductive biology and endocrinology : RB&E · 2021Article
- The Role of GnIH in Biological Rhythms and Social Behaviors.Frontiers in endocrinology · 2021Review
- Gonadotropin Inhibitory Hormone and Its Receptor: Potential Key to the Integration and Coordination of Metabolic Status and Reproduction.Frontiers in endocrinology · 2021Review
- Kisspeptin and Testicular Function-Is it Necessary?International journal of molecular sciences · 2020Review
- Reproductive neuroendocrinology of mammalian gonadotropin-inhibitory hormone.Reproductive medicine and biology · 2019Review
- Article
- Functional Implications of RFRP-3 in the Central Control of Daily and Seasonal Rhythms in Reproduction.Frontiers in endocrinology · 2019Review
- The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction.Iranian journal of basic medical sciences · 2018Review
- Endotoxin rapidly desensitizes the gonads to kisspeptin-induced luteinizing hormone release in male Siberian hamsters (The Journal of experimental biology · 2018Article
- Gonadotrophin-inhibitory hormone and its mammalian orthologue RFamide-related peptide-3: Discovery and functional implications for reproduction and stress.Journal of neuroendocrinology · 2018Review
- Comparative and Evolutionary Aspects of Gonadotropin-Inhibitory Hormone and FMRFamide-Like Peptide Systems.Frontiers in neuroscience · 2018Article
- How to Contribute to the Progress of Neuroendocrinology: Discovery of GnIH and Progress of GnIH Research.Frontiers in endocrinology · 2018Review
- Is precocious puberty linked to hypothalamic expression of arginine-phenylalanine-amide-related peptide?Iranian journal of basic medical sciences · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
RFamide-related peptide (RFRP), the mammalian homolog of avian gonadotropin-inhibitory hormone, has a pronounced suppressive action on the reproductive axis across species. In mammals, RFRP acts directly on GnRH neurons, and likely at the level of the pituitary, to inhibit gonadotropin secretion. In the present study, we examined whether RFRP might act outside of mammalian brain on reproductive tissues directly. Using RT-PCR and in situ hybridization, we found that both RFRP and its receptors [G protein-coupled receptor (GPR) 147 and GPR74] are expressed in the testis of Syrian hamster. These results were confirmed and extended using double- and triple-label immunohistochemistry. RFRP expression was observed in spermatocytes and in round to early elongated spermatids. Significant expression of RFRP was not seen in Leydig cells. GPR147 protein was observed in myoid cells in all stages of spermatogenesis, pachytene spermatocytes, maturation division spermatocytes, and in round and late elongated spermatids. GPR74 proteins only appeared in late elongated spermatids. Additionally, we found that RFRP and its receptor mRNA are markedly altered by day length and reproductive condition. These findings highlight a possible novel autocrine and/or paracrine role for RFRP in Syrian hamster testis, potentially contributing to the differentiation of spermatids during spermiogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.