ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2010
Identification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturity.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- SPOCK2 controls the proliferation and function of immature pancreatic β-cells through MMP2.Experimental & molecular medicine · 2025Article
- Engineered extracellular vesicles from human skin cells induce pro-β-cell conversions in pancreatic ductal cells.Advanced nanobiomed research · 2023Article
- Validating expression of beta cell maturation-associated genes in human pancreas development.Frontiers in cell and developmental biology · 2023Article
- Fetal Programming of the Endocrine Pancreas: Impact of a Maternal Low-Protein Diet on Gene Expression in the Perinatal Rat Pancreas.International journal of molecular sciences · 2022Article
- Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes.Molecular metabolism · 2021Article
- Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability.Molecular metabolism · 2020Article
- Pancreatic and Islet Remodeling in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Knockout Ferrets.The American journal of pathology · 2018Article
- Surfactant Protein D in Respiratory and Non-Respiratory Diseases.Frontiers in medicine · 2018Review
- Dynamic development of the pancreas from birth to adulthood.Upsala journal of medical sciences · 2016Review
- Article
- A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells.Nature communications · 2016Article
- Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo.Molecular endocrinology (Baltimore, Md.) · 2016Article
- Pancreatic β Cell Mass Death.Frontiers in pharmacology · 2016Review
- Proper activation of MafA is required for optimal differentiation and maturation of pancreatic β-cells.Best practice & research. Clinical endocrinology & metabolism · 2015Review
- A Historical Perspective on the Identification of Cell Types in Pancreatic Islets of Langerhans by Staining and Histochemical Techniques.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015Article
- DNA methylation directs functional maturation of pancreatic β cells.The Journal of clinical investigation · 2015Article
- Article
- Formation of a human β-cell population within pancreatic islets is set early in life.The Journal of clinical endocrinology and metabolism · 2012Article
- Deconstructing pancreas developmental biology.Cold Spring Harbor perspectives in biology · 2012Review
- The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells.Diabetologia · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Markers of beta-cell maturity would be useful in staging the differentiation of stem/progenitor cells to beta-cells whether in vivo or in vitro. We previously identified markers for newly formed beta-cells in regenerating rat pancreases after 90% partial pancreatectomy. To test the generality of these markers of newly formed beta-cells, we examined their expression during the perinatal period, a time of recognized beta-cell immaturity. We show by semiquantitative RT-PCR and immunostaining over the time course from embryonic day 18/20 to birth, 1 day, 2 days, 3 days, 7 days, and adult that MMP-2, CK-19, and SPD are truly markers of new and immature beta-cells and that their expression transiently peaks in the perinatal period and is not entirely synchronous. The shared expression of these markers among fetal, newborn, and newly regenerated beta-cells, but not adult, strongly supports their use as potential markers for new beta-cells in the assessment of both the maturity of stem cell-derived insulin-producing cells and the presence of newly formed islets (neogenesis) in the adult pancreas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.