ArticleEMBO molecular medicine2009
Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells.
Article in EMBO molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 45 citations in OpenAlex.
- The predawn dilemma in adeno-associated virus-based gene therapies for hereditary deafness.American journal of stem cells · 2025Review
- VezA/vezatin facilitates proper assembly of the dynactin complex in vivo.Cell reports · 2024Article
- VezA/vezatin facilitates proper assembly of the dynactin complex in vivo.bioRxiv : the preprint server for biology · 2024Article
- Activation of Src Kinase Mediates the Disruption of Adherens Junction in the Blood-labyrinth Barrier after Acoustic Trauma.Current neurovascular research · 2024Article
- The noncoding genome and hearing loss.Human genetics · 2022Review
- Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity.Cell death & disease · 2021Article
- Exome sequencing utility in defining the genetic landscape of hearing loss and novel-gene discovery in Iran.Clinical genetics · 2021Article
- Radixin modulates the function of outer hair cell stereocilia.Communications biology · 2020Article
- A Conserved Role for Vezatin Proteins in Cargo-Specific Regulation of Retrograde Axonal Transport.Genetics · 2020Article
- Differential Effects of Low- and High-Dose Dexamethasone on Electrically Induced Damage of the Cultured Organ of Corti.Neurotoxicity research · 2020Article
- Coronin 3 Promotes the Development of Oncogenic Properties in Glioma Through the Wnt/β-Catenin Signaling Pathway.OncoTargets and therapy · 2020Article
- Vezatin is required for the maturation of the neuromuscular synapse.Molecular biology of the cell · 2019Article
- The endocochlear potential as an indicator of reticular lamina integrity after noise exposure in mice.Hearing research · 2018Article
- Transcriptional profiling of leukocytes from rheumatoid arthritis patients before and after anti-tumor necrosis factor therapy: A comparison of anti-nuclear antibody positive and negative subsets.Experimental and therapeutic medicine · 2017Article
- Analysis ofJournal of gastric cancer · 2017Article
- QTL Mapping of Endocochlear Potential Differences between C57BL/6J and BALB/cJ mice.Journal of the Association for Research in Otolaryngology : JARO · 2016Article
- Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBA/CaJ Mice.Neural plasticity · 2016Article
- Progressive Hearing Loss in Mice Carrying a Mutation in Usp53.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Discovery of a vezatin-like protein for dynein-mediated early endosome transport.Molecular biology of the cell · 2015Article
- Genetics of auditory mechano-electrical transduction.Pflugers Archiv : European journal of physiology · 2015Review
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15 authors at 7 institutions in 3 countries.
Funding
Abstract
Loud sound exposure is a significant cause of hearing loss worldwide. We asked whether a lack of vezatin, an ubiquitous adherens junction protein, could result in noise-induced hearing loss. Conditional mutant mice bearing non-functional vezatin alleles only in the sensory cells of the inner ear (hair cells) indeed exhibited irreversible hearing loss after only one minute exposure to a 105 dB broadband sound. In addition, mutant mice spontaneously underwent late onset progressive hearing loss and vestibular dysfunction related to substantial hair cell death. We establish that vezatin is an integral membrane protein with two adjacent transmembrane domains, and cytoplasmic N- and C-terminal regions. Late recruitment of vezatin at junctions between MDCKII cells indicates that the protein does not play a role in the formation of junctions, but rather participates in their stability. Moreover, we show that vezatin directly interacts with radixin in its actin-binding conformation. Accordingly, we provide evidence that vezatin associates with actin filaments at cell-cell junctions. Our results emphasize the overlooked role of the junctions between hair cells and their supporting cells in the auditory epithelium resilience to sound trauma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.