ArticleAnnals of biomedical engineering2010
Incorporating histology into a 3D microscopic computer model of myocardium to study propagation at a cellular level.
Article in Annals of biomedical engineering, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- A possible path to persistent re-entry waves at the outlet of the left pulmonary vein.NPJ systems biology and applications · 2024Article
- Efficient, cell-based simulations of cardiac electrophysiology; The Kirchhoff Network Model (KNM).NPJ systems biology and applications · 2023Article
- A cell-based framework for modeling cardiac mechanics.Biomechanics and modeling in mechanobiology · 2023Article
- Confocal microscopy-based estimation of intracellular conductivities in myocardium for modeling of the normal and infarcted heart.Computers in biology and medicine · 2022Article
- Arrhythmogenic influence of mutations in a myocyte-based computational model of the pulmonary vein sleeve.Scientific reports · 2022Article
- It's clearly the heart! Optical transparency, cardiac tissue imaging, and computer modelling.Progress in biophysics and molecular biology · 2022Article
- Deriving the Bidomain Model of Cardiac Electrophysiology From a Cell-Based Model; Properties and Comparisons.Frontiers in physiology · 2021Article
- From Millimeters to Micrometers; Re-introducing Myocytes in Models of Cardiac Electrophysiology.Frontiers in physiology · 2021Article
- An audit of uncertainty in multi-scale cardiac electrophysiology models.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Review
- Computational modeling of cardiac growth and remodeling in pressure overloaded hearts-Linking microstructure to organ phenotype.Acta biomaterialia · 2020Review
- Properties of cardiac conduction in a cell-based computational model.PLoS computational biology · 2019Article
- Atrial Rotor Dynamics Under Complex Fractional Order Diffusion.Frontiers in physiology · 2018Article
- Modeling dynamics in diseased cardiac tissue: Impact of model choice.Chaos (Woodbury, N.Y.) · 2017Article
- Virtual cardiac monolayers for electrical wave propagation.Scientific reports · 2017Article
- Article
- Cardiac response to low-energy field pacing challenges the standard theory of defibrillation.Circulation. Arrhythmia and electrophysiology · 2015Article
- Simulations of complex and microscopic models of cardiac electrophysiology powered by multi-GPU platforms.Computational and mathematical methods in medicine · 2012Article
- Probing field-induced tissue polarization using transillumination fluorescent imaging.Biophysical journal · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We introduce a 3D model of cardiac tissue to study at a microscopic level the relationship between tissue morphology and propagation of depolarization. Unlike the classical bidomain approach, in which tissue properties are described by the apparent conductivity of the tissue, in this "microdomain" approach, we included histology by modeling the actual shape of the intracellular and extracellular spaces that contain spatially distributed gap-junctions and membranes. The histological model of the tissue was generated by a computer algorithm that can be tuned to model different histological changes. For healthy tissue, the model predicted a realistic conduction velocity of 0.42 m/s based solely on the parameters derived from histology. A comparison with a brick-shaped, simplified model showed that conduction depended to a moderate extent on the shape of myocytes; a comparison with a one-dimensional bidomain model with the same overall shape and structure showed that the apparent conductivity of the tissue can be used to create an equivalent bidomain model. In summary, the microdomain approach offers a means of directly incorporating structural and functional parameters into models of cardiac activation and propagation and thus provides a valuable bridge between the cellular and tissue domains in the myocardium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.