ArticleCerebellum (London, England)2012
Calcium influx measured at single presynaptic boutons of cerebellar granule cell ascending axons and parallel fibers.
Article in Cerebellum (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Beyond synaptic plasticity: a summary of a linear model of the cerebellar locomotor computation.Frontiers in neural circuits · 2026Review
- Computational anatomy: the cerebellar microzone computation.Oxford open neuroscience · 2025Article
- Fiber-basedNeurophotonics · 2024Article
- Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex.Frontiers in pharmacology · 2024Article
- Mitofusin 2 Sustains the Axonal Mitochondrial Network to Support Presynaptic CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- How and Why the Cerebellum Recodes Input Signals: An Alternative to Machine Learning.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Article
- A stable proportion of Purkinje cell inputs from parallel fibers are silent during cerebellar maturation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Phase-Locking Requires Efficient CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Slow-decaying presynaptic calcium dynamics gate long-lasting asynchronous release at the hippocampal mossy fiber to CA3 pyramidal cell synapse.Synapse (New York, N.Y.) · 2020Article
- Article
- Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice.Annals of neurology · 2015Article
- The ubiquitous nature of multivesicular release.Trends in neurosciences · 2015Review
- In vivo analysis of Purkinje cell firing properties during postnatal mouse development.Journal of neurophysiology · 2015Article
- Activation of extrasynaptic NMDARs at individual parallel fiber-molecular layer interneuron synapses in cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Functional contributions of the plasma membrane calcium ATPase and the sodium-calcium exchanger at mouse parallel fibre to Purkinje neuron synapses.Pflugers Archiv : European journal of physiology · 2013Article
- Release properties of individual presynaptic boutons expressed during homosynaptic depression and heterosynaptic facilitation of the Aplysia sensorimotor synapse.Frontiers in cellular neuroscience · 2013Article
- A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition.PloS one · 2013Article
- Diversity and complexity of roles of granule cells in the cerebellar cortex. Editorial.Cerebellum (London, England) · 2012Article
- Models of calcium dynamics in cerebellar granule cells.Cerebellum (London, England) · 2012Review
- Synchrony and neural coding in cerebellar circuits.Frontiers in neural circuits · 2012Article
Corrections and comments
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2 authors.
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Abstract
Action potential-evoked calcium influx into presynaptic boutons is a key determinant of synaptic strength and function. Here, we have examined the calcium dynamics at individual presynaptic boutons of the cerebellar granule cells in the molecular layer of cerebellar slices and investigated whether different subpopulations of granule cell boutons exhibit different calcium dynamics. We found that a population of boutons with low basal calcium clearance rates may activate a second clearance mechanism and exhibit biphasic calcium decay on high calcium influx induced by bursts of action potentials. We also found that boutons on ascending axons and parallel fibers show similar calcium influx amplitudes and calcium clearance rates in response to action potentials. Lastly, we found that parallel fiber boutons located in the inner molecular layer have a higher calcium clearance rate than boutons located in the outer molecular layer. These results suggest that cerebellar granule cell boutons should not be regarded as a homogeneous population, but rather that different subpopulations of boutons may exhibit different properties. The heterogeneity of presynaptic boutons may allow different learned behaviors to be encoded in the same circuit without mutual interference and may be a general mechanism for increasing the computational capacity of the brain.
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