ArticleInternational ophthalmology2010
Intra-ocular expression of vascular endothelial growth factor (VEGF) and pigment epithelial-derived factor (PEDF) in a case of Eales' disease by immunohistochemical analysis: a case report.
Article in International ophthalmology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 8 citations in OpenAlex.
- Eales' disease: epidemiology, diagnostic and therapeutic concepts.International journal of retina and vitreous · 2022Article
- Intravitreal bevacizumab as an adjunct to vitrectomy in advanced Eales' disease.Journal of ophthalmic inflammation and infection · 2012Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
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Abstract
We report a immunohistochemical study of expression of VEGF and PEDF in Eales' disease. An enucleated eye from a patient with Eales' disease and an age and sex-matched donor eyeball were subjected to immunohistochemical and histopathological analysis to study the expression of VEGF and PEDF in the retinal region. Strong positive anti-VEGF immunostaining was found around the vessel walls in the retina in the eyeball from the Eales' disease patient compared with the donor control, from which it was almost absent. PEDF staining was detected in the normal donor eyeball retinal layers surrounding the blood vessels, and the photoreceptor and ganglion cell layer, whereas in the eyeball from Eales' disease patient PEDF staining was restricted to the surrounding blood vessels. The strong expression of VEGF in eyes with Eales' disease as opposed to weak expression of PEDF indicates the propensity of the disease to show neovascularization and recurrent hemorrhages.
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