ReviewPflugers Archiv : European journal of physiology2010
ClC transporters: discoveries and challenges in defining the mechanisms underlying function and regulation of ClC-5.
Review in Pflugers Archiv : European journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Interference with megalin expression/endocytic function by montelukast mitigates gentamicin nephrotoxicity: Downregulation of ClC-5 expression.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- Dent disease: classification, heterogeneity and diagnosis.World journal of pediatrics : WJP · 2021Review
- A Compendium of Information on the Lysosome.Frontiers in cell and developmental biology · 2021Review
- Functional and transport analyses of CLCN5 genetic changes identified in Dent disease patients.Physiological reports · 2016Article
- Prolactin stimulates sodium and chloride ion channels in A6 renal epithelial cells.American journal of physiology. Renal physiology · 2015Article
- A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome.Pharmacogenetics and genomics · 2015Article
- Double Xp11.22 deletion including SHROOM4 and CLCN5 associated with severe psychomotor retardation and Dent disease.Molecular cytogenetics · 2015Article
- Slc26a11 is prominently expressed in the brain and functions as a chloride channel: expression in Purkinje cells and stimulation of V H⁺-ATPase.Pflugers Archiv : European journal of physiology · 2013Article
- Novel diuretic targets.American journal of physiology. Renal physiology · 2013Review
- The CLC-5 2Cl(-)/H(+) exchange transporter in endosomal function and Dent's disease.Frontiers in physiology · 2012Article
- Involvement of the tubular ClC-type exchanger ClC-5 in glomeruli of human proteinuric nephropathies.PloS one · 2012Article
- Role of the ubiquitin system in regulating ion transport.Pflugers Archiv : European journal of physiology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The involvement of several members of the chloride channel (ClC) family of membrane proteins in human disease highlights the need to define the mechanisms underlying their function and the consequences of disease-causing mutations. Despite the utility of high-resolution structural models, our understanding of the molecular basis for function of the chloride channels and transporters in the family remains incomplete. In this review, we focus on recent discoveries regarding molecular mechanisms underlying the regulated chloride:proton antiporter activity of ClC-5, the protein mutated in the Dent's disease-a kidney disease presenting with proteinuria and renal failure in severe cases. We discuss the putative role of ClC-5 in receptor-mediated endocytosis and protein uptake by the proximal renal tubule and the possible molecular and cellular consequences of disease-causing mutations. However, validation of these models will require future study of the intrinsic function of this transporter, in situ, in the membranes of recycling endosomes in proximal tubule epithelial cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.