SynthesisHuman genetics2010
A meta-analysis of three polymorphisms in the endothelial nitric oxide synthase gene (NOS3) and their effect on the risk of diabetic nephropathy.
Synthesis in Human genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Genetic association studies of endothelial nitric oxide synthase gene polymorphisms in women with unexplained recurrent pregnancy loss: a systematic and meta-analysis.Molecular biology reports · 2014Pooled it
- Phosphodiesterase Type 5 Inhibition Reduces Albuminuria in Subjects with Overt Diabetic Nephropathy.Journal of the American Society of Nephrology : JASN · 2016Trial
- Mechanism ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Genetic Variants and Their Associations to Type 2 Diabetes Mellitus Complications in the United Arab Emirates.Frontiers in endocrinology · 2021Article
- Study of the Active Components and Molecular Mechanism ofFrontiers in molecular biosciences · 2021Article
- Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease.Cardiovascular diabetology · 2018Article
- Endothelial nitric oxide synthase gene (T786C and G894T) polymorphisms in Egyptian patients with type 2 diabetes.Journal, genetic engineering & biotechnology · 2017Article
- Polymorphisms of Antioxidant Genes as a Target for Diabetes Management.International journal of molecular and cellular medicine · 2017Review
- Age and gender differences in the influences of eNOS T-786C polymorphism on arteriosclerotic parameters in general population in Japan.Environmental health and preventive medicine · 2016Article
- Glucose Tolerance,Journal of diabetes research · 2016Article
- Association of genetic variants with diabetic nephropathy.World journal of diabetes · 2014Review
- Article
- Nitric oxide system and diabetic nephropathy.Diabetology & metabolic syndrome · 2014Article
- Susceptibility gene search for nephropathy and related traits in Mexican-Americans.Molecular biology reports · 2013Review
- Polymorphisms in nitric oxide synthase and endothelin genes among children with obstructive sleep apnea.BMC medical genomics · 2013Article
- Endothelial nitric oxide synthase gene polymorphism (G894T) and diabetes mellitus (type II) among South Indians.Oxidative medicine and cellular longevity · 2011Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of association studies have investigated the role of the nitric oxide synthase 3 (NOS3) gene in the development of diabetic nephropathy (DN). However, results have been inconclusive, largely because the studies have focused on a variety of different polymorphisms and generate inconsistent results. We performed a meta-analysis of 28 association studies focusing on three polymorphisms in the NOS3 gene (G894T (Glu289Asp), 4b/a, and T-786C) and the risk of DN published before July 2009, covering a total of 10,364 subjects. Although significant heterogeneity was initially found in the analysis of G894T, it did not remain when analysis was done by ethnic subgroups. 894T was negatively associated with DN in Caucasian populations of European origin (OR = 0.896, 0.817-0.983, 95% CI), but was positively associated with DN in East Asian (OR = 2.02, 1.20-3.42, 95% CI) and other populations. Association of the 4b/a variant was observed when studies involving microalbuminuria were excluded (OR = 1.19, 1.02-1.39, 95% CI). The T-786C variant showed an overall weak association (OR = 1.16, 1.01-1.34, 95% CI) with little heterogeneity. In summary, our meta-analysis of the effect of NOS3 gene polymorphisms on the risk of DN supports the involvement of the NOS3 gene in the pathogenesis of DN.
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