ArticleRheumatology international2012
An infant with severe refractory Crohn's disease and homozygous MEFV mutation who dramatically responded to colchicine.
Article in Rheumatology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Precision medicine in monogenic inflammatory bowel disease: proposed mIBD REPORT standards.Nature reviews. Gastroenterology & hepatology · 2023Review
- Tripartite motif family proteins in inflammatory bowel disease: Mechanisms and potential for interventions.Cell proliferation · 2022Review
- North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper on the Evaluation and Management for Patients With Very Early-onset Inflammatory Bowel Disease.Journal of pediatric gastroenterology and nutrition · 2020Article
- Familial Mediterranean fever: What associations to screen for?Reumatologia · 2020Review
- Coexisting Diseases in Patients with Familial Mediterranean Fever.Open access rheumatology : research and reviews · 2020Article
- Neonatal ulcerative colitis associated with Familial Mediterranean fever: a case report.Rheumatology international · 2018Article
- Newcomers in paediatric GI pathology: childhood enteropathies including very early onset monogenic IBD.Virchows Archiv : an international journal of pathology · 2018Review
- The role of monogenic disease in children with very early onset inflammatory bowel disease.Current opinion in pediatrics · 2017Review
- Exome sequencing analysis reveals variants in primary immunodeficiency genes in patients with very early onset inflammatory bowel disease.Gastroenterology · 2015Article
- Maintaining intestinal health: the genetics and immunology of very early onset inflammatory bowel disease.Cellular and molecular gastroenterology and hepatology · 2015Article
- Familial Mediterranean fever in which Crohn's disease was suspected: a case report.BMC research notes · 2014Article
- Inflammatory bowel disease: An archetype disorder of outer environment sensor systems.World journal of gastrointestinal pharmacology and therapeutics · 2013Article
- Bloody Diarrhea as a Presentation Manifestation of Familial Mediterranean Fever in a Patient with Compound Heterozygote Mutations of the MEFV Gene.Gut and liver · 2013Article
- Genomic and Immunologic Drivers of Very Early-Onset Inflammatory Bowel Disease.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology SocietyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have suggested that inflammatory bowel disease is particulary frequent and severe in familial Mediterranean fever (FMF) families. An 8-month-old boy was admitted to our hospital with chronic bloody diarrhea, failure to thrive and high-grade fever. He was diagnosed as Crohn's disease (CD) based on clinical, laboratory and histological findings and, corticosteroid therapy was started. The patient did not respond to intensive medical therapy including intravenous corticosteroid, mesalazine, azathioprine, intravenous cyclosporine and enteral feeding. MEFV gene mutation analysis revealed homozygous M694V mutation. In addition to azathioprine and cyclosporine therapy, with the diagnosis of FMF, colchicine therapy was started and partial remission was observed within 2 weeks. To the best of our knowledge, this is the first report of association of CD and FMF in an infant. In cases of CD resistant to medical therapy, possibility of underlying FMF should be considered, especially in countries where FMF is prevalent.
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