ArticleInternational journal of endocrinology2010
Does vitamin d deficiency cause hypertension? Current evidence from clinical studies and potential mechanisms.
Article in International journal of endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- The Impact of Vitamin D Deficiency and Insufficiency on the Outcome of Type 2 Diabetes Mellitus Patients: A Systematic Review.Nutrients · 2023Pooled it
- Importance of assessing erectile dysfunction in patients with type 2 diabetes mellitus based on glucose fluctuation: a Cross-Sectional study.Endocrine · 2025Article
- Vitamin - D deficiency as a risk factor in primary hypertension - A cross sectional study.Bioinformation · 2025Article
- 25-hydroxyvitamin D as a predictor of reduced heart rate variability in elderly patients with diabetes mellitus.Frontiers in endocrinology · 2025Article
- Vitamin D deficiency in patients with retinal vein occlusion: a systematic review and meta-analysis.International journal of retina and vitreous · 2024Review
- Vitamin D-A New Therapeutic Target in the Management of Type 2 Diabetes Patients.Journal of clinical medicine · 2024Article
- Generative Artificial Intelligence in Patient Education: ChatGPT Takes on Hypertension Questions.Cureus · 2024Article
- Using Machine Learning to Identify the Relationships between Demographic, Biochemical, and Lifestyle Parameters and Plasma Vitamin D Concentration in Healthy Premenopausal Chinese Women.Life (Basel, Switzerland) · 2023Article
- The Effects of Vitamin D Supplementation before 20 Weeks of Gestation on Preeclampsia: A Systematic Review.Journal of personalized medicine · 2023Review
- Latest Knowledge on the Role of Vitamin D in Hypertension.International journal of molecular sciences · 2023Review
- Vitamin D Deficiency Is a Potential Risk for Blood Pressure Elevation and the Development of Hypertension.Medicina (Kaunas, Lithuania) · 2021Article
- The relationship between serum 25-hydroxy vitamin D and blood pressure and quality of life in overweight and obese patients with type 2 diabetes mellitus compared with healthy subjects.Caspian journal of internal medicine · 2020Article
- Article
- Genetic Epidemiologic Analysis of Hypertensive Retinopathy in an Underrepresented and Rare Federally Recognized Native American Population of the Intermountain West.Journal of community medicine & public health · 2019Article
- Familial clustering of vitamin D deficiency via shared environment: The Korean National Health and Nutrition Examination Survey 2008-2012.European journal of clinical nutrition · 2018Article
- The Antioxidant Therapy: New Insights in the Treatment of Hypertension.Frontiers in physiology · 2018Review
- The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements.Nutrients · 2017Article
- The associations of vitamin D status and dietary calcium with the metabolic syndrome: an analysis of the Victorian Health Monitor survey.Public health nutrition · 2017Article
- New light on an old vitamin: The role of the sunshine vitamin D in chronic disease.Reviews in endocrine & metabolic disorders · 2017Article
- Vitamin-D concentrations, cardiovascular risk and events - a review of epidemiological evidence.Reviews in endocrine & metabolic disorders · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D deficiency is widely prevalent across all ages, races, geographical regions, and socioeconomic strata. In addition to its important role in skeletal development and calcium homeostasis, several recent studies suggest its association with diabetes, hypertension, cardiovascular disease, certain types of malignancy, and immunologic dysfunction. Here, we review the current evidence regarding an association between vitamin D deficiency and hypertension in clinical and epidemiological studies. We also look into plausible biological explanations for such an association with the renin-angiotensin-aldosterone system and insulin resistance playing potential roles. Taken together, it appears that more studies in more homogeneous study populations are needed before a firm conclusion can be reached as to whether vitamin D deficiency causes or aggravates hypertension and whether vitamin D supplementation is safe and exerts cardioprotective effects. The potential problems with bias and confounding factors present in previous epidemiological studies may be overcome or minimized by well designed randomized controlled trials in the future.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.