ReviewMolecular psychiatry2010
Advances in molecular genetics of panic disorder.
Review in Molecular psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 6 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Panic disorder during pregnancy and the first three years after delivery: a systematic review.BMC pregnancy and childbirth · 2025Pooled it
- Meta-analysis of genome-wide association studies of anxiety disorders.Molecular psychiatry · 2016Pooled it
- Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways.Molecular psychiatry · 2016Pooled it
- Meta-analysis of genome-wide association studies for panic disorder in the Japanese population.Translational psychiatry · 2012Pooled it
- Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes.European journal of human genetics : EJHG · 2012Pooled it
- Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders.Biological psychiatry · 2011Pooled it
- Fear Circuits in Panic Disorder: An Update.Alpha psychiatry · 2025Review
- Breaking the Fear Barrier: Aberrant Activity of Fear Networks as a Prognostic Biomarker in Patients with Panic Disorder Normalized by Pharmacotherapy.Biomedicines · 2023Article
- Article
- Genetics of Anxiety Disorders.Current psychiatry reports · 2019Review
- Assessment of fear and anxiety associated behaviors, physiology and neural circuits in rats with reduced serotonin transporter (SERT) levels.Translational psychiatry · 2019Article
- A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety.Translational psychiatry · 2018Article
- Panic disorders: The role of genetics and epigenetics.AIMS genetics · 2018Review
- Assessing Panic: Bridging the Gap Between Fundamental Mechanisms and Daily Life Experience.Frontiers in neuroscience · 2018Review
- GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder.Molecular psychiatry · 2017Article
- Cross-generational influences on childhood anxiety disorders: pathways and mechanisms.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Impaired Facial Affect Perception in Unaffected Children at Familial Risk for Panic Disorder.Child psychiatry and human development · 2015Article
- Validation of candidate anxiety disorder genes using a carbon dioxide challenge task.Biological psychology · 2015Article
- Polymorphisms of IKBKE gene are associated with major depressive disorder and panic disorder.Brain and behavior · 2015Article
- Evidence for Association between the Brain-Derived Neurotrophic Factor Gene and Panic Disorder: A Novel Haplotype Analysis.Psychiatry investigation · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular genetic research on panic disorder (PD) has grown tremendously in the past decade. Although the data from twin and family studies suggest an involvement of genetic factors in the familial transmission of PD with the heritability estimate near 40%, the genetic substrate underlying panicogenesis is not yet understood. The linkage studies so far have suggested that chromosomal regions 13q, 14q, 22q, 4q31-q34, and probably 9q31 are associated with the transmission of PD phenotypes. To date, more than 350 candidate genes have been examined in association studies of PD, but most of these results remain inconsistent, negative, or not clearly replicated. Only Val158Met polymorphism of the catechol-O-methyltransferase gene has been implicated in susceptibility to PD by several studies in independent samples and confirmed in a recent meta-analysis. However, the specific role of this genetic variation in PD requires additional analysis considering its gender- and ethnicity-dependent effect and putative impact on cognitive functions. The recent advantages in bioinformatics and genotyping technologies, including genome-wide association and gene expression methods, provide the means for far more comprehensive discovery in PD. The progress in clinical and neurobiological concepts of PD may further guide genetic research through the current controversies to more definitive findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.