ArticlePlastic and reconstructive surgery2010
Rodent facial nerve recovery after selected lesions and repair techniques.
Article in Plastic and reconstructive surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- The potential role of SCF combined with DPCs in facial nerve repair.Journal of molecular histology · 2025Article
- The SELENOT mimetic PSELT promotes nerve regeneration by increasing axonal myelination in a facial nerve injury model in female rats.Journal of neuroscience research · 2022Article
- Facial Nerve Repair: Bioengineering Approaches in Preclinical Models.Tissue engineering. Part B, Reviews · 2022Review
- Promoting and Orienting Axon Extension Using Scaffold-Free Dental Pulp Stem Cell Sheets.ACS biomaterials science & engineering · 2022Article
- Delivery of Interleukin-4-Encoding Lentivirus Using Multiple-Channel Bridges Enhances Nerve Regeneration.The Laryngoscope · 2020Article
- Comparison of Myelin-Associated Glycoprotein With Vincristine for Facial Nerve Inhibition After Bilateral Axotomy in a Transgenic Thy1-Gfp Rat Model.JAMA facial plastic surgery · 2019Article
- Effect of Motor versus Sensory Nerve Autografts on Regeneration and Functional Outcomes of Rat Facial Nerve Reconstruction.Scientific reports · 2019Article
- Electrophysiological assessment of a peptide amphiphile nanofiber nerve graft for facial nerve repair.Journal of tissue engineering and regenerative medicine · 2018Article
- The effects of venous ensheathment on facial nerve repair in the rat.The Laryngoscope · 2017Article
- Synaptic plasticity in the facial nucleus in rats following infraorbital nerve manipulation after facial nerve injury.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Optimal site for facial nerve transection and neurorrhaphy: a randomized prospective animal study.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2015Article
- Long-term functional recovery after facial nerve transection and repair in the rat.Journal of reconstructive microsurgery · 2015Article
- Activation and measurement of free whisking in the lightly anesthetized rodent.Nature protocols · 2014Article
- A system for delivering mechanical stimulation and robot-assisted therapy to the rat whisker pad during facial nerve regeneration.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2013Article
- Quantitative analysis of muscle histologic method in rodent facial nerve injury.JAMA facial plastic surgery · 2013Article
- The convergence of facial nerve branches providing whisker pad motor supply in rats: implications for facial reanimation study.Muscle & nerve · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMeasuring rodent facial movements is a reliable method for studying recovery from facial nerve manipulation and for examining the behavioral correlates of aberrant regeneration. The authors quantitatively compared recovery of vibrissal and ocular function following three types of clinically relevant nerve injury.
methodsOne hundred seventy-eight adult rats underwent facial nerve manipulation and testing. In the experimental groups, the left facial nerve was either crushed, transected, and repaired epineurially, or transected and the stumps suture-secured into a tube with a 2-mm gap between them. Facial recovery was measured for the ensuing 1 to 4 months. Data were analyzed for whisking recovery. Previously developed markers of co-contraction of the upper and midfacial zones (possible synkinesis markers) were also examined.
resultsAnimals in the crush groups recovered nearly normal whisking parameters within 25 days. The distal branch crush group showed improved recovery over the main trunk crush group for several days during early recovery. By week 9, the transection/repair groups showed evidence of recovery that trended further upward throughout the study period. The entubulation groups followed a similar recovery pattern, although they did not maintain significant recovery levels by the study conclusion. Markers of potential synkinesis increased in selected groups following facial nerve injury.
conclusionsRodent vibrissal function recovers in a predictable fashion following manipulation. Generalized co-contraction of the upper and midfacial zones emerges following facial nerve manipulation, possibly related to aberrant regeneration, polyterminal axons, or hypersensitivity of the rodent to sensory stimuli following nerve manipulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.