Evidence map›Paper›PMID 20048245›Full record

ArticleArchives of pediatrics & adolescent medicine2010

Incidence and seasonality of hypothermia among newborns in southern Nepal.

Luke C Mullany, Joanne Katz, Subarna K Khatry, Steven C Leclerq, Gary L Darmstadt, James M Tielsch

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Archives of pediatrics & adolescent medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00109616 (Newborn Antiseptic Washing and Neonatal Mortality-Nepal), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00109616 phase3completednot on this map

Newborn Antiseptic Washing and Neonatal Mortality-Nepal

TypeinterventionalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2002 to 2006Enrolled17,000ConditionsNeonatal MortalityArmsNewborn skin cleansing with 0.25% chlorhexidine solution, Cleansing of umbilical cord with soap and water solution, Cleansing of umbilical cord with 4% chlorhexidine
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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  19. Market mechanisms for newborn health in Nepal.BMC pregnancy and childbirth · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Luke C MullanyInternational Center for Advancing Neonatal Health, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe St, Ste E8646, Baltimore, MD 21205,USA. lmullany@jhsph.edu
Joanne Katz
Subarna K Khatry
Steven C Leclerq
Gary L Darmstadt
James M Tielsch
Johns Hopkins University · USBill & Melinda Gates Foundation · US

Funding

ZINC SUPPLEMENTATION IMPACT ON CHILD MORTALITY--NEPALR01HD038753 · NICHD · JOHNS HOPKINS UNIVERSITY · PI TIELSCH, JAMES M · 2000 to 2003
$3.5M
Newborn Antiseptic Washing and Neonatal Mortality-NepalR01HD044004 · NICHD · JOHNS HOPKINS UNIVERSITY · PI TIELSCH, JAMES M · 2003 to 2005
$1.5M
Incidence, risk factors, and consequences of neonatal hypothermia in NepalR03HD055346 · NICHD · JOHNS HOPKINS UNIVERSITY · PI MULLANY, LUKE C · 2007 to 2008
$162k
NICHD NIH HHS HD 38753NICHD NIH HHS HD 44004NICHD NIH HHS HD 553466NICHD NIH HHS R01 HD038753NICHD NIH HHS R01 HD044004NICHD NIH HHS R03 HD055346
6 · The paper itself

Abstract

objectiveTo quantify incidence, age distribution, and seasonality of neonatal hypothermia among a large population cohort.

designLongitudinal cohort study.

settingSarlahi, Nepal.

participantsA total of 23 240 newborns born between September 2, 2002, and February 1, 2006. Main Exposures Community-based workers recorded axillary temperature on days 1 through 4, 6, 8, 10, 12, 14, 21, and 28 (213 636 total measurements).

main outcome measuresRegression smoothing was used to describe axillary temperature patterns during the newborn period. Hypothermia incidence in the first day, week, and month were estimated using standard cutoffs. Ambient temperatures allowed comparison of mild hypothermia (36.0 degrees C to <36.5 degrees C) and moderate or severe hypothermia (<36.0 degrees C) incidence over mean ambient temperature quintiles.

resultsMeasurements lower than 36.5 degrees C were observed in 21 459 babies (92.3%); half (48.6%) had moderate or severe hypothermia, and risk peaked in the first 24 to 72 hours of life. Risk of moderate or severe hypothermia increased by 41.3% (95% confidence interval, 40.0%-42.7%) for every 5 degrees C decrease in average ambient temperature. Relative to the highest quintile, risk was 4.03 (95% confidence interval, 3.77-4.30) times higher among babies exposed to the lowest quintile of average ambient temperature. In the hot season, one-fifth of the babies (18.2%) were observed below the moderate hypothermia cutoff.

conclusionsMild or moderate hypothermia was nearly universal, with substantially higher risk in the cold season. However, incidence in the hot season was also high; thus, year-round thermal care promotion is required. Research on community, household, and caretaker practices associated with hypothermia can guide behavioral interventions to reduce risk.

Indexed as

Age DistributionFemaleHumansHypothermiaIncidenceInfant, NewbornMaleNepalRural PopulationSeasons

Identifiers

PMID20048245
PMCPMC4546825
OpenAlexW2037607696

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.