ArticleMolecular and cellular biology2010
Asf1 can promote trimethylation of H3 K36 by Set2.
Article in Molecular and cellular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Functional analysis of chromatin-associated proteins in Sordaria macrospora reveals similar roles for RTT109 and ASF1 in development and DNA damage response.G3 (Bethesda, Md.) · 2024Article
- Chromatin balances cell redox and energy homeostasis.Epigenetics & chromatin · 2023Review
- The Role of Chromatin Assembly Factors in Induced Mutagenesis at Low Levels of DNA Damage.Genes · 2023Article
- Structural and functional specificity of H3K36 methylation.Epigenetics & chromatin · 2022Review
- Set2 histone methyltransferase regulates transcription coupled-nucleotide excision repair in yeast.PLoS genetics · 2022Article
- H3K36 trimethylation-mediated biological functions in cancer.Clinical epigenetics · 2021Review
- The determinants of alternative RNA splicing in human cells.Molecular genetics and genomics : MGG · 2017Review
- Shaping the cellular landscape with Set2/SETD2 methylation.Cellular and molecular life sciences : CMLS · 2017Review
- Modulation of gene expression dynamics by co-transcriptional histone methylations.Experimental & molecular medicine · 2017Review
- Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.Nucleic acids research · 2016Article
- Balancing acts of SRI and an auto-inhibitory domain specify Set2 function at transcribed chromatin.Nucleic acids research · 2015Article
- Single cell analysis of RNA-mediated histone H3.3 recruitment to a cytomegalovirus promoter-regulated transcription site.The Journal of biological chemistry · 2013Article
- Dissecting the roles of the histone chaperones reveals the evolutionary conserved mechanism of transcription-coupled deposition of H3.3.Nucleic acids research · 2013Article
- Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes.Nature · 2012Article
- Inositol phosphate kinase Vip1p interacts with histone chaperone Asf1p in Saccharomyces cerevisiae.Molecular biology reports · 2012Article
- Understanding the language of Lys36 methylation at histone H3.Nature reviews. Molecular cell biology · 2012Review
- Promoter regulation by distinct mechanisms of functional interplay between lysine acetylase Rtt109 and histone chaperone Asf1.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Novel histone H3 binding protein ORF158L from the Singapore grouper iridovirus.Journal of virology · 2011Article
- Elongator complex influences telomeric gene silencing and DNA damage response by its role in wobble uridine tRNA modification.PLoS genetics · 2011Article
- The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1.Nucleic acids research · 2011Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Asf1 is a conserved histone H3/H4 chaperone that can assemble and disassemble nucleosomes and promote histone acetylation. Set2 is an H3 K36 methyltransferase. The functions of these proteins intersect in the context of transcription elongation by RNA polymerase II: both contribute to the establishment of repressive chromatin structures that inhibit spurious intragenic transcription. Here we characterize further interactions between budding yeast (Saccharomyces cerevisiae) Asf1 and Set2 using assays of intragenic transcription, H3/H4 posttranslational modification, coding region cross-linking of Asf1 and Set2, and cooccurrence of Asf1 and Set2 in protein complexes. We find that at some genes Asf1 and Set2 control chromatin metabolism as components of separate pathways. However, the existence of a low-abundance complex containing both proteins suggests that Asf1 and Set2 can more directly collaborate in chromatin regulation. Consistent with this possibility, we show that Asf1 stimulates Set2 occupancy of the coding region of a highly transcribed gene by a mechanism that depends on Asf1 binding to H3/H4. This function of Asf1 promotes the switch from di- to trimethylation of H3 K36 at that gene. These results support the view that Set2 function in chromatin metabolism can intimately involve histone chaperone Asf1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.