Evidence map›Paper›PMID 20047997›Full record

ArticleGenes & development2010

Switching the mechanism of mating type switching: a domesticated transposase supplants a domesticated homing endonuclease.

Laura N Rusche, Jasper Rine

Open access · diamondAbstract readComment
In one paragraph

Article in Genes & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Evolutionary mysteries in meiosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016
    Review
  10. Article
  11. Origins of eukaryotic sexual reproduction.Cold Spring Harbor perspectives in biology · 2014
    Review
  12. Beyond the ENCODE project: using genomics and epigenomics strategies to study enhancer evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013
    Review
  13. Article
  14. Article
  15. Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Laura N RuscheInstitute for Genome Sciences and Policy, and Biochemistry Department, Duke University, Durham, North Carolina 27708, USA.
Jasper Rine
Duke University · USQB3 · US

Funding

GENETIC ANALYSIS OF THE GENES CONTROLLING A POSITIONR01GM031105 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI RINE, JASPER D · 1985 to 2020
$6.4M
GENETIC ANALYSIS OF GENES CONTROLLING A POSITION EFFECTR37GM031105 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI RINE, JASPER D · 1999 to 2008
$3.5M
Chromatin-Mediated Mechanisms of Gene RepressionR01GM073991 · NIGMS · DUKE UNIVERSITY · PI RUSCHE, LAURA N · 2005 to 2010
$1.4M
NIGMS NIH HHS GM073991NIGMS NIH HHS GM31105NIGMS NIH HHS R01 GM031105NIGMS NIH HHS R01 GM073991NIGMS NIH HHS R37 GM031105
6 · The paper itself

Abstract

Programmed DNA rearrangements are critical for the development of many organisms and, intriguingly, can be catalyzed by domesticated mobile genetic elements. In this issue of Genes & Development, Barsoum and colleagues (pp. 33-44) demonstrate that, in the budding yeast Kluyveromyces lactis, a DNA rearrangement associated with mating type switching requires a domesticated transposase and occurs through a mechanism distinct from that in the related yeast, Saccharomyces cerevisiae. Thus, mechanisms for mating type switching have evolved multiple times, indicating the relative ease with which mobile genetic elements can be captured.

Indexed as

DNA Transposable ElementsEndonucleasesEvolution, MolecularGene RearrangementGene SilencingGenes, Mating Type, FungalKluyveromycesSaccharomyces cerevisiaeTransposasesDNA Transposable ElementsEndonucleasesTransposases

Identifiers

PMID20047997
PMCPMC2802186
OpenAlexW2030900349

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.