ArticleNucleic acids research2010
Mph1 requires mismatch repair-independent and -dependent functions of MutSalpha to regulate crossover formation during homologous recombination repair.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Rad51, Rad54, and ZMM proteins antagonize the mismatch repair system to promote fertility of budding yeast intraspecies hybrid zygotes.Nucleic acids research · 2025Article
- Factors that influence bidirectional long-tract homozygosis due to double-strand break repair in Candida albicans.Genetics · 2021Article
- Factors enforcing the species boundary between the human pathogens Cryptococcus neoformans and Cryptococcus deneoformans.PLoS genetics · 2021Article
- Collaborations between chromatin and nuclear architecture to optimize DNA repair fidelity.DNA repair · 2021Review
- Moving forward one step back at a time: reversibility during homologous recombination.Current genetics · 2019Review
- Dynamic Processing of Displacement Loops during Recombinational DNA Repair.Molecular cell · 2019Article
- A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination.Molecular cell · 2018Article
- Review
- Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases.Genetics · 2014Article
- Template switching during break-induced replication is promoted by the Mph1 helicase in Saccharomyces cerevisiae.Genetics · 2014Article
- Resolution by unassisted Top3 points to template switch recombination intermediates during DNA replication.The Journal of biological chemistry · 2013Article
- Mph1 and Mus81-Mms4 prevent aberrant processing of mitotic recombination intermediates.Molecular cell · 2013Article
- Heteroduplex DNA position defines the roles of the Sgs1, Srs2, and Mph1 helicases in promoting distinct recombination outcomes.PLoS genetics · 2013Article
- Roles of DNA helicases in the mediation and regulation of homologous recombination.Advances in experimental medicine and biology · 2013Article
- Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities.DNA repair · 2011Article
- The roles of the Saccharomyces cerevisiae RecQ helicase SGS1 in meiotic genome surveillance.PloS one · 2010Article
- A genome-wide analysis reveals no nuclear dobzhansky-muller pairs of determinants of speciation between S. cerevisiae and S. paradoxus, but suggests more complex incompatibilities.PLoS genetics · 2010Article
- Molecular structures of crossover and noncrossover intermediates during gap repair in yeast: implications for recombination.Molecular cell · 2010Article
- Regulation of homologous recombination in eukaryotes.Annual review of genetics · 2010Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In budding yeast the DNA helicase Mph1 prevents genome rearrangements during ectopic homologous recombination (HR) by suppressing the formation of crossovers (COs). Here we show that during ectopic HR repair, the anti-CO function of Mph1 is intricately associated with the mismatch repair (MMR) factor, MutSalpha. In particular, during HR repair using a completely homologous substrate, we reveal an MMR-independent function of MutSalpha in generating COs that is specifically antagonized by Mph1, but not Sgs1. In contrast, both Mph1 and MutSalpha are required to efficiently suppress COs in the presence of a homeologous substrate. Mph1 acts redundantly with Sgs1 in this respect since mph1Delta sgs1Delta double mutant cells pheno-copy MutSalpha mutants and completely fail to discriminate homologous and homeologous sequences during HR repair. However, this defect of mph1Delta sgs1Delta cells is not due to an inability to carry out MMR but rather is accompanied by elevated levels of gene conversion (GC) and bi-directional GC tracts specifically in non-crossover products. Models describing how Mph1, MutSalpha and Sgs1 act in concert to suppress genome rearrangements during ectopic HR repair are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.