ArticleEvidence-based complementary and alternative medicine : eCAM2011
Isolation of Bioactive Compounds That Relate to the Anti-Platelet Activity of Cymbopogon ambiguus.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- 1,8-Cineole Affects Agonists-Induced Platelet Activation, Thrombus Formation and Haemostasis.Cells · 2021Article
- Revealing the Pharmacological Mechanism ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- HPLC-Guided Isolation, Purification and Characterization of Phenylpropanoid and Phenolic Constituents of Nutmeg Kernel (Myristica fragrans).Natural product communications · 2016Article
- Cymbopogon species; ethnopharmacology, phytochemistry and the pharmacological importance.Molecules (Basel, Switzerland) · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infusions and decoctions of Cymbopogon ambiguus have been used traditionally in Australia for the treatment of headache, chest infections and muscle cramps. The aim of the present study was to screen and identify bioactive compounds from C. ambiguus that could explain this plant's anti-headache activity. A dichloromethane extract of C. ambiguus was identified as having activity in adenosine-diphosphate-induced human platelet aggregation and serotonin-release inhibition bioassays. Subsequent fractionation of this extract led to the isolation of four phenylpropenoids, eugenol, elemicin, eugenol methylether and trans-isoelemicin. While both eugenol and elemicin exhibited dose-dependent inhibition of ADP-induced human platelet serotonin release, only eugenol displayed potent inhibitory activity with an IC50 value of 46.6 μ M, in comparison to aspirin, with an IC50 value of 46.1 μ M. These findings provide evidence to support the therapeutic efficacy of C. ambiguus in the non-conventional treatment of headache and inflammatory conditions.
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Registered trials
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