Evidence map›Paper›PMID 20047828›Full record

ArticleBiosensors & bioelectronics2010

Sensitive giant magnetoresistive-based immunoassay for multiplex mycotoxin detection.

Andy C Mak, Sebastian J Osterfeld, Heng Yu, Shan X Wang, Ronald W Davis, Olufisayo A Jejelowo, Nader Pourmand

Abstract readEvaluation Study
In one paragraph

Article in Biosensors & bioelectronics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Giant Magnetoresistance Biosensors in Biomedical Applications.ACS applied materials & interfaces · 2022
    Review
  4. (Bio)nanotechnology in Food Science-Food Packaging.Nanomaterials (Basel, Switzerland) · 2021
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Plant pathogen nanodiagnostic techniques: forthcoming changes?Biotechnology, biotechnological equipment · 2014
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Ultrasensitive mycotoxin detection by STING sensors.Biosensors & bioelectronics · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andy C MakStanford Genome Technology Center, Stanford University, 855 California Ave, Palo Alto, CA 94304, USA.
Sebastian J Osterfeld
Heng Yu
Shan X Wang
Ronald W Davis
Olufisayo A Jejelowo
Nader Pourmand

Funding

WHOLE YEAST GENOME TRANSCRIPTIONAL AND FUNCTIONAL GENE MAPS--A FEASIBILITY STUDYP01HG000205 · NHGRI · STANFORD UNIVERSITY · PI DAVIS, RONALD WAYNE, HOWE, ROGER THOMAS · 1990 to 2016
$120.9M
NHGRI NIH HHS P01 HG000205NHGRI NIH HHS P01-HG000205
6 · The paper itself

Abstract

Rapid and multiplexed measurement is vital in the detection of food-borne pathogens. While highly specific and sensitive, traditional immunochemical assays such as enzyme-linked immunosorbent assays (ELISAs) often require expensive read-out equipment (e.g. fluorescent labels) and lack the capability of multiplex detection. By combining the superior specificity of immunoassays with the sensitivity and simplicity of magnetic detection, we have developed a novel multiplex magnetic nanotag-based detection platform for mycotoxins that functions on a sub-picomolar concentration level. Unlike fluorescent labels, magnetic nanotags (MNTs) can be detected with inexpensive giant magnetoresistive (GMR) sensors such as spin-valve sensors. In the system presented here, each spin-valve sensor has an active area of 90 microm x 90 microm, arranged in an 8 x 8 array. Sample is added to the antibody-immobilized sensor array prior to the addition of the biotinylated detection antibody. The sensor response is recorded in real time upon the addition of streptavidin-linked MNTs on the chip. Here we demonstrate the simultaneous detection of multiple mycotoxins (aflatoxins B(1), zearalenone and HT-2) and show that a detection limit of 50 pg/mL can be achieved.

Indexed as

Biosensing TechniquesConductometryElectric ImpedanceEquipment DesignEquipment Failure AnalysisFood AnalysisFood ContaminationImmunoassayMagneticsMycotoxinsMycotoxins

Identifiers

PMID20047828
PMCPMC2947153

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.