ArticleGenome biology2010
Genomic characterization of the Yersinia genus.
Article in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57 citing papers in PubMed, 120 citations in OpenAlex.
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- Mutational Effects on Carbapenem Hydrolysis of YEM-1, a New Subclass B2 Metallo-β-Lactamase from Yersinia mollaretii.Antimicrobial agents and chemotherapy · 2020Article
- Conservation ofInternational journal of systematic and evolutionary microbiology · 2020Article
- A Recombinant AttenuatedInfection and immunity · 2019Article
- Editorial: The Pathogenic Yersiniae-Advances in the Understanding of Physiology and Virulence, Second Edition.Frontiers in cellular and infection microbiology · 2019Article
- Genome Sequencing ofFrontiers in microbiology · 2019Article
- Occurrence ofInfection ecology & epidemiology · 2018Article
- The Infection Process ofFrontiers in cellular and infection microbiology · 2018Review
- Brief Protocol for EDGE Bioinformatics: Analyzing Microbial and Metagenomic NGS Data.Bio-protocol · 2017Article
- Enabling the democratization of the genomics revolution with a fully integrated web-based bioinformatics platform.Nucleic acids research · 2017Article
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Authors and funding
16 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundNew DNA sequencing technologies have enabled detailed comparative genomic analyses of entire genera of bacterial pathogens. Prior to this study, three species of the enterobacterial genus Yersinia that cause invasive human diseases (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) had been sequenced. However, there were no genomic data on the Yersinia species with more limited virulence potential, frequently found in soil and water environments.
resultsWe used high-throughput sequencing-by-synthesis instruments to obtain 25- to 42-fold average redundancy, whole-genome shotgun data from the type strains of eight species: Y. aldovae, Y. bercovieri, Y. frederiksenii, Y. kristensenii, Y. intermedia, Y. mollaretii, Y. rohdei, and Y. ruckeri. The deepest branching species in the genus, Y. ruckeri, causative agent of red mouth disease in fish, has the smallest genome (3.7 Mb), although it shares the same core set of approximately 2,500 genes as the other members of the species, whose genomes range in size from 4.3 to 4.8 Mb. Yersinia genomes had a similar global partition of protein functions, as measured by the distribution of Cluster of Orthologous Groups families. Genome to genome variation in islands with genes encoding functions such as ureases, hydrogenases and B-12 cofactor metabolite reactions may reflect adaptations to colonizing specific host habitats.
conclusionsRapid high-quality draft sequencing was used successfully to compare pathogenic and non-pathogenic members of the Yersinia genus. This work underscores the importance of the acquisition of horizontally transferred genes in the evolution of Y. pestis and points to virulence determinants that have been gained and lost on multiple occasions in the history of the genus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.